一种二甲双胍渗透泵控释片的制备方法技术

本发明专利技术涉及一种二甲双胍渗透泵控释片的制备方法，用于治疗2型糖尿病。包括制备片芯、包半透膜层、打孔、干燥、包防潮层，其特征在于：制备片芯时，加入二甲双胍的药用盐和非离子表面活性剂，非离子表面活性剂占二甲双胍的药用盐的2～20wt.％。本发明专利技术药物释放平稳，对肠道无刺激，给药次数少，患者易于接受且顺应性大为提高。

Preparation method of metformin osmotic pump controlled release tablet

The present invention relates to a preparation method of metformin osmotic pump controlled release tablet for treating type 2 diabetes mellitus. Including the preparation of the tablet core, punching, drying, semipermeable layer, package moistureproof layer, which is characterized in that the preparation of the tablet core, adding metformin pharmaceutically acceptable salts and non-ionic surfactants, nonionic surfactants for medicinal salt of metformin was 2 ~ 20wt.%. The medicine has the advantages of stable release, no irritation to the intestinal tract, less number of administration, easy acceptance of the patient and good compliance.

【技术实现步骤摘要】

【技术保护点】
１．一种二甲双胍渗透泵控释片的制备方法，包括制备片芯、包半透膜层、打孔、干燥、包防潮层，其特征在于：制备片芯时，加入二甲双胍的药用盐和非离子表面活性剂，非离子表面活性剂占二甲双胍的药用盐的２～２０ｗｔ．％。

【技术特征摘要】

【专利技术属性】
技术研发人员：汪洋，潘西海，孙艳华，郑忠辉，
申请(专利权)人：山东新华制药股份有限公司，
类型：发明
国别省市：37