The present invention provides a compound of formula I or pharmaceutically acceptable salt, new compounds, including histone deacetylase inhibitory activity of 4 aromatic amino quinazoline hydroxamic acids of the compound, preparation method, pharmaceutical compositions containing the compounds and the compounds and the pharmaceutical composition in preparing histone deacetylase inhibitors to use drugs; to get a series based on the 4 Fang aminoquinazoline for identifying the enzyme surface and connected region area through optimizing drug design and synthesis of selective histone subtype selectivity and good pharmacokinetic properties. Histone deacetylase inhibitors, and to enhance the antitumor activity to reduce the impact on normal tissue or cells.
【技术实现步骤摘要】
【国外来华专利技术】PCT国内申请，说明书已公开。
【技术保护点】
PCT国内申请，权利要求书已公开。
【技术特征摘要】
【国外来华专利技术】2015.03....
【专利技术属性】
技术研发人员：陈俐娟，龙超峰，陈小新，刘卓伟，叶昊宇，谢称石，
申请(专利权)人：广东众生药业股份有限公司，
类型：发明
国别省市：广东,44
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