一种格列吡嗪渗透泵控释片的制备方法技术

本发明专利技术涉及一种格列吡嗪渗透泵控释片的制备方法，包括将制备好的格列吡嗪片芯经包半透膜层、激光打孔和包防潮层制成，其特征在于制备格列吡嗪片芯包括制备固体分散体和制备片芯。本发明专利技术采用的固体分散技术显著提高了药物的溶解速度，助溶性的辅料提高了格列吡嗪的溶解度，并适量加入促渗透剂来调节渗透压力达到恒速或接近恒速释放。本发明专利技术具有工艺简单、成本低、病人易接受和治疗效果好的优点。

Preparation method of glipizide osmotic pump controlled release tablet

The invention relates to a method of glipizide osmotic pump controlled release tablets were prepared, including the Glipizide Tablets core prepared by a semipermeable membrane bag layer, laser drilling and moisture-proof layer made, characterized in that the preparation of Glipizide Tablets core includes the preparation of solid dispersion and preparation of core tablets. The invention adopts the solid dispersion technology can significantly improve the dissolution rate of drugs, hydrotropy materials improve the solubility of glipizide, and adding a penetration promoting agent to regulate the osmotic pressure at constant speed or near constant speed release. The invention has the advantages of simple process, low cost, easy acceptance of the patient and good treatment effect.

【技术实现步骤摘要】

【技术保护点】
１．一种格列吡嗪渗透泵控释片的制备方法，包括将制备好的格列吡嗪片芯，经包半透膜层、激光打孔和包防潮层制成，其特征是制备格列吡嗪片芯包括如下步骤：（１）制备固体分散体：将格列吡嗪和药学上可接受的辅料分散于溶剂中，搅拌均匀，经干燥、粉碎后，得格列吡嗪固体分散体；（２）制备片芯：将格列吡嗪固体分散体和药学上可接受的辅料混匀，压片，制备格列吡嗪片芯。

【技术特征摘要】

【专利技术属性】
技术研发人员：汪洋，潘西海，孙艳华，郑忠辉，
申请(专利权)人：山东新华制药股份有限公司，
类型：发明
国别省市：37