一种具有CSF1R抑制活性的氮杂芳基衍生物、其制备方法和应用技术

本发明专利技术提供了一种具有CSF1R抑制活性的氮杂芳基衍生物、其制备方法和应用。本发明专利技术系列化合物具有如下式(Ⅰ)结构，各取代基的定义如说明书和权利要求书所述。本发明专利技术系列化合物可广泛应用于制备治疗癌症、肿瘤、自身免疫性疾病、代谢性疾病或转移性疾病的药物，特别是治疗卵巢癌、胰腺癌、前列腺癌、乳腺癌、宫颈癌、成胶质细胞瘤、多发性骨髓瘤、代谢性疾病、神经变性疾病、原发性肿瘤位点的转移或骨转移性癌症的药物，有望开发成新一代CSF1R抑制剂药物。

A heteroaryl derivative with csf1r inhibitory activity, its preparation and Application

The invention provides a heteroaryl derivative with csf1r inhibiting activity, a preparation method and application thereof. The series of compounds of the invention have the structure of formula (I) as follows, and the definition of each substituent is as described in the description and claims. The compounds of the invention can be widely used in the preparation of drugs for the treatment of cancer, tumor, autoimmune disease, metabolic disease or metastatic disease, especially for the treatment of ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, metastasis of primary tumor site or bone metastatic cancer It is expected to develop a new generation of csf1r inhibitors.

【技术实现步骤摘要】
【国外来华专利技术】PCT国内申请，说明书已公开。

【技术保护点】
PCT国内申请，权利要求书已公开。/n

【技术特征摘要】
【国外来华专利技术】20170619...

【专利技术属性】
技术研发人员：张鸣鸣，赵保卫，喻红平，陈椎，徐耀昌，
申请(专利权)人：上海和誉生物医药科技有限公司，
类型：发明
国别省市：上海;31