The present invention relates to the field of biological protein, polypeptide and its use in particular to hemostatic transformation, transformation of the tree core hemostasis in a polypeptide composed of branched lysine with two dimers A and two dimers B, two peptide dimers A as shown by as shown in the SEQIDNO:1 polypeptide and SEQIDNO:2 are connected in series a two mer B peptide as shown by as shown in the SEQIDNO:3 polypeptide and SEQIDNO:2 are connected in series to the end of valine lysine core polypeptide dendrimers consisting of the same SEQIDNO:2 shows the connection; the transformation of the hemostatic polypeptide can be used for the preparation of hemostatic drugs; hemostatic hemostatic effect is better than shown in the polypeptide such as SEQIDNO:1, SEQIDNO:2 and SEQIDNO:3 amino acid sequence, its stability is better; when using the same dose, the coagulation effect is better.
【技术实现步骤摘要】
【技术保护点】
１．改造的止血多肽，其特征在于：在由一个赖氨酸构成的树状核心的分枝上连接有二聚体Ａ和二聚体Ｂ，所述二聚体Ａ由如ＳＥＱ ＩＤ ＮＯ：１所示的多肽和ＳＥＱ ＩＤ ＮＯ：２所示的多肽依次串联而成，所述二聚体Ｂ由如ＳＥＱ ＩＤ ＮＯ：３所示的多肽和ＳＥＱ ＩＤ ＮＯ：２所示的多肽依次串联而成，所述改造的止血多肽的赖氨酸构成的树状核心同ＳＥＱ ＩＤ ＮＯ：２所示的多肽的末端缬氨酸连接。
【技术特征摘要】
【专利技术属性】
技术研发人员：杨霞，吴玉章，李晋涛，
申请(专利权)人：中国人民解放军第三军医大学，
类型：发明
国别省市：85
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