一种含有蛋白质或多肽的口服制剂、其制备方法及用途技术

本发明专利技术属于药物学和制剂学领域，涉及一种含有蛋白质或多肽的口服制剂、其制备方法及用途。具体地，涉及一种乳剂，其包含蛋白质或多肽、水相、油相、乳化剂，其特征在于，所述油相含有中链脂肪酸酯，并且所述乳化剂包括HLB值大于12的乳化剂。制得的乳剂在保持较高的生物利用度的同时，保持优异的乳化性能。本发明专利技术的乳剂在被水稀释时，能均匀分散，生成的乳滴粒径分布比较均匀，不会导致乳液不清。

An oral preparation containing a protein or polypeptide, a process for its preparation and use thereof

The invention belongs to the field of pharmacology and pharmaceutics, relates to an oral preparation containing protein or polypeptide, preparation method and application thereof. Specifically, relates to an emulsion comprising a protein or polypeptide, water phase, oil phase, emulsifier, which is characterized in that the oil phase containing medium chain fatty acid ester, and the emulsifier including emulsifier HLB value greater than 12. The prepared emulsions maintain excellent emulsifying properties while maintaining high bioavailability. When the emulsion is diluted by water, the emulsion can be evenly dispersed, and the size distribution of the milk drops is relatively uniform, and the emulsion is not clear.

【技术实现步骤摘要】

【技术保护点】
１．一种乳剂，包含蛋白质或多肽、水相、油相、乳化剂，其特征在于，所述油相含有中链脂肪酸酯，并且所述乳化剂包括ＨＬＢ值大于１２的乳化剂。

【技术特征摘要】

【专利技术属性】
技术研发人员：马二利，郑昌学，
申请(专利权)人：美迪思生物科技北京有限公司，
类型：发明
国别省市：11