一种长链脂肪酸的糖醇酯及其分离提取方法和在抑制芳香化酶活性中的应用技术

本发明专利技术公开了一种长链脂肪酸的糖醇酯，即如式１所示的化合物亚麻酸山梨醇酯，以及它的制备方法。本发明专利技术的化合物未见报道，且其芳香化酶抑制活性比游离的脂肪酸强。本发明专利技术还公开了这种长链脂肪酸的糖醇酯或含其的植物提取物在制备抑制芳香化酶活性的制剂中的应用和在制备预防和治疗前列腺增生疾病的药物组合物中的应用。

Sugar alcohol ester of long chain fatty acid and its separation and extraction method and application in inhibiting aromatase activity

The invention discloses a sugar alcohol esters of long chain fatty acids, linolenic acid sorbitol ester compounds as shown in Formula 1, and its preparation method. The compounds of the present invention have not been reported, and their aromatase inhibitory activity is stronger than that of free fatty acids. Application of preparation of the invention also discloses a sugar alcohol ester of the long-chain fatty acid or a plant extract containing the same preparation for the inhibition of aromatase activity and pharmaceutical compositions for prevention and treatment of prostatic hyperplasia in preparation of.

【技术实现步骤摘要】

【技术保护点】
一种如式１所示的长链脂肪酸的糖醇酯，即亚麻酸山梨醇酯。　＊＊＊　式１。

【技术特征摘要】

【专利技术属性】
技术研发人员：杨义芳，李永辉，李坤，杨念云，
申请(专利权)人：上海医药工业研究院，
类型：发明
国别省市：31[中国|上海]