一种能联合免疫细胞增强肿瘤杀伤能力的双特异性抗体及其制备方法和应用技术

本发明专利技术提供了一种能联合免疫细胞增强肿瘤靶向杀伤能力的双特异性抗体及其制备方法和应用。通过采用化学方法连接抗体和可降解的纳米颗粒，一个纳米颗粒上同时连接两种或两种以上多个抗体分子，其中一种抗体能够特异结合免疫细胞，另一种或几种抗体可以特异结合肿瘤细胞，从而起到增强免疫细胞靶向特异杀伤肿瘤细胞的效果。

A combination of immune cells enhanced tumor killing ability of bispecific antibody and its preparation method and Application

The invention provides a combined immune cells enhanced tumor targeting killing ability of bispecific antibody and its preparation method and application. Attached to the antibody and degradable nanoparticles by using chemical method, a nano particles and connecting two or more than two kinds of antibody molecules, one of the antibodies could specifically bind immune cells, the other one or several specific antibodies can be combined with tumor cells, so as to enhance the immune cells targeting specific killing tumor the effect of cell.

【技术实现步骤摘要】
【国外来华专利技术】PCT国内申请，说明书已公开。

【技术保护点】
PCT国内申请，权利要求书已公开。

【技术特征摘要】
【国外来华专利技术】2015.04....

【专利技术属性】
技术研发人员：于浩洋，李正成，苏静，
申请(专利权)人：本康生物制药深圳有限公司，
类型：发明
国别省市：广东,44