Nobiliside A隐形纳米脂质体静脉注射液及其制备方法技术

本发明专利技术涉及医药技术领域，是具有抗肿瘤活性的Nobiliside?A的一种隐形纳米脂质体静脉注射液制剂及其制备方法，组分和配比为：Nobiliside?A?0.01-100mg/mL；磷脂1-50mg/mL；胆固醇0.01-20mg/mL；PEG脂质0.1-20mg/mL；注射用水，余量。动物实验表明，本发明专利技术Nobiliside?A隐形纳米脂质体静脉注射液制剂比Nobiliside?A的普通脂质体静脉注射液制剂半衰期长，对肝脏和脾脏的毒副作用小，抑瘤率比Nobiliside?A普通脂质体静脉注射液提高了约30％。本发明专利技术Nobiliside?A隐形纳米脂质体静脉注射液制备方法简单，能有效提高Nobiliside?A的抑瘤率，降低Nobiliside?A的毒副作用。

Nobiliside A stealth nano liposome intravenous injection and preparation method thereof

The present invention relates to the technical field of medicine, has the antitumor activity of Nobiliside? A a stealth nano liposomes intravenous injection and its preparing method, composition and proportion: Nobiliside? A? 0.01-100mg/mL 1-50mg/mL 0.01-20mg/mL cholesterol; phospholipid; lipid; PEG 0.1-20mg/mL; injection water margin. Animal experiments show that the invention of Nobiliside? A stealth nano liposomes for intravenous injection preparation than Nobiliside? A liposome preparation for intravenous injection has a long half-life, liver and spleen small toxic side effect, the inhibition rate than Nobiliside? A liposomes for intravenous injection is improved by about 30%. The preparation method of the Nobiliside A stealth nano liposome vein injection is simple, and can effectively improve the anti-tumor rate of Nobiliside and A, and reduce the toxic and side effects of Nobiliside and A.

【技术实现步骤摘要】

【技术保护点】
１．一种Ｎｏｂｉｌｉｓｉｄｅ　Ａ隐形纳米脂质体静脉注射液，组分和配比如下：其中，磷脂选自大豆卵磷脂、蛋黄卵磷脂、二硬脂酰磷脂酰胆碱、二棕榈酰磷脂酰胆碱、二肉豆蔻酰磷脂酰胆碱中的一种或几种；ＰＥＧ脂质选自聚乙二醇－二硬脂酰磷脂酰乙醇胺、聚乙二醇－聚己内酯、聚乙二醇－聚乙交酯丙交酯、聚乙二醇－聚乳酸、聚乙二醇－聚十六烷基氰基丙烯酸酯、聚氧乙烯脂肪酸醚、聚氧乙烯甲基蓖麻油醚中的一种或几种。

【技术特征摘要】

【专利技术属性】
技术研发人员：陈建明，顾芃，张莹莹，马露露，净晓龙，揭继龙，张佳良，高保安，崔晓如，
申请(专利权)人：中国人民解放军第二军医大学，
类型：发明
国别省市：31