新型多层多糖结构修饰的血红蛋白脂质体纳米囊血液替代品制造技术

新型多层多糖结构修饰的血红蛋白脂质体纳米囊血液替代品，本发明专利技术涉及牛血红蛋白纳米囊血液替代品及其制备方法，该纳米囊含有一带正电荷的脂质体内核，外层通过层层自组装的方法用壳聚糖/葡聚糖酸钠这对多糖类的聚电解质进行修饰，其血红蛋白含量高且载氧活性很接近天然红细胞；所述方法通过七个步骤进行，最终得到包裹了7层聚电解质的纳米囊，L-(DE-CH)3-DE（L:Liposome,即内层的脂质体层；DE:Dextran,CH:Chiotsan），收集最终产物；该制备方法，工艺简单，所用有机溶剂少，反应过程温和，对血红蛋白等的生物性能影响小。?

Novel multilayer polysaccharide structural modified hemoglobin liposome nanocapsules for blood substitutes

A novel multi-layer structure of polysaccharide modified hemoglobin liposome nano capsule blood substitutes, the present invention relates to bovine hemoglobin blood substitute nano capsule and a preparation method of the nano capsule containing positively charged liposomes with outer kernel, chitosan / dextran sodium on the polysaccharide polyelectrolyte modified by layer by layer the assembly method, the content of hemoglobin and oxygen carrier activity is very close to natural red blood cells; the method is carried out through seven steps, finally wrapped up the 7 layer polyelectrolyte nanoparticles, L- (DE-CH) 3-DE (L:Liposome, namely the liposome layer; the inner DE:Dextran, CH:Chiotsan), collect the final product; the preparation method has the advantages of simple process, with less organic solvent, reaction is mild, affect the biological properties of hemoglobin and other small. ?

【技术实现步骤摘要】

【技术保护点】
１．新型的多层多糖结构修饰的血红蛋白脂质体纳米囊血液替代品，其特征在于：该纳米囊含有一带正电荷的脂质体内核，外层通过层层自组装的方法用壳聚糖／葡聚糖酸钠这对多糖类的聚电解质进行修饰。

【技术特征摘要】
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【专利技术属性】
技术研发人员：张惠，唐君，徐礼鲜，
申请(专利权)人：中国人民解放军第四军医大学，
类型：发明
国别省市：87