一种用于治疗肝癌的肿瘤疫苗及其制备方法技术

一种用于治疗肝癌的肿瘤疫苗及其制备方法，该治疗效果改进的肝癌疫苗包括肝癌细胞分泌的exosomes小体，所述的肝癌细胞是经过Cephaloziellins J和SAHA联合加药处理的，Cephaloziellins J和SAHA的摩尔浓度之比为0.8～1.2∶1。通过使用Cephaloziellins J和SAHA加药处理肝癌细胞，结果表明，处理后的肝癌细胞分泌的exosomes及其可溶性免疫分子则能显著改善前述的抑制作用，显著提高了exosomes肿瘤疫苗治疗效果，具有重要的临床应用价值。

A tumor vaccine for the treatment of liver cancer and its preparation method

For a tumor vaccine and its preparation method for the treatment of liver cancer, improve the therapeutic effect of the liver cancer vaccines include secretion of human hepatoma cells exosomes hepatoma cell bodies, the combined treatment of Cephaloziellins after dosing J and SAHA, Cephaloziellins J and SAHA molar ratio of 0.8 to 1.2: 1. By using Cephaloziellins J and SAHA AGENT-DOSING hepatoma cells, the results show that the secretion of hepatoma cells after treatment of exosomes and its soluble immune molecules can significantly improve the inhibitory effect, can significantly improve the therapeutic effect of exosomes tumor vaccine, has important clinical value.

【技术实现步骤摘要】
【国外来华专利技术】PCT国内申请，说明书已公开。

【技术保护点】
PCT国内申请，权利要求书已公开。

【技术特征摘要】
【国外来华专利技术】2015.10....

【专利技术属性】
技术研发人员：李淑兰，
申请(专利权)人：李淑兰，
类型：发明
国别省市：山东,37