The present invention relates to cholic acid derivatives, their preparation methods and medical uses. Specifically, the present invention relates to a cholic acid derivative having a I structure, its stereoisomers, or pharmaceutically acceptable salts thereof. This series of compounds can be used in the treatment for the treatment of FXR mediated diseases, including cardiovascular disease, atherosclerosis, arteriosclerosis, high blood cholesterol, high blood lipid and chronic hepatitis, chronic liver disease, gastrointestinal disease, kidney disease, cardiovascular disease, metabolic disease, cancer (e.g. colorectal cancer) or neurological signs such as stroke and other diseases, has a wide range medical applications, is expected to develop into a new generation of FXR agonists.
【技术实现步骤摘要】
【国外来华专利技术】PCT国内申请,说明书已公开。
【技术保护点】
PCT国内申请,权利要求书已公开。
【技术特征摘要】
【国外来华专利技术】2015.04....
【专利技术属性】
技术研发人员:李成海,包如迪,吕爱锋,钟慧娟,
申请(专利权)人:江苏豪森药业集团有限公司,上海翰森生物医药科技有限公司,
类型:发明
国别省市:江苏,32
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