酞嗪酮衍生物、其制备方法及用途技术

本申请涉及酞嗪酮衍生物、其制备方法及用途；具体涉及一种式I化合物、其前体药物、代谢物形式、药学上可接受的盐或酯、或前述的异构体、水合物、溶剂合物或晶型，其制备方法及用途，本申请的化合物可以明显提高对肿瘤细胞的增殖抑制作用；可以增加分子体内稳定性以及降低产生毒性代谢物的可能性；或者，可通过降低对酞嗪酮类化合物的结构修饰，降低化合物在体内P450细胞色素酶系作用下的氧化代谢能力，并提高了生物利用率，

Chalcone derivatives, process for their preparation and use thereof

The invention relates to phthalazinone derivatives, preparation method and application thereof; and particularly relates to a compound of formula I, its prodrug, metabolite forms, pharmaceutically acceptable salt or ester, or the isomers, hydrates, solvates or crystal, its preparation method and application of the compound the application can significantly improve on tumor cell proliferation inhibition; can increase the stability and reduce the possibility of molecules in vivo to produce toxic metabolites; or, by reducing the structural modification of phthalazine ketones, ability to reduce the oxidative metabolism of compounds in the cytochrome P450 enzyme system under the action of the body, and improve the biological utilization rate,

【技术实现步骤摘要】
【国外来华专利技术】PCT国内申请，说明书已公开。

【技术保护点】
PCT国内申请，权利要求书已公开。

【技术特征摘要】
【国外来华专利技术】2015.12....

【专利技术属性】
技术研发人员：刘钢，于华，任云，杜静，杨定菊，李晓勇，王坤建，刘伟，唐建川，吴勇勇，曾宏，卿燕，宋宏梅，李少华，葛勇，王利春，王晶翼，
申请(专利权)人：四川科伦博泰生物医药股份有限公司，
类型：发明
国别省市：四川,51