The invention relates to a preparation method of pasiniazide, comprising the steps of: 1) the amount of water and organic solvent are mixed; mixing, heating of aminosalicylic acid and isoniazid added to the solvent water and organic solvents, 2); cooling crystallization, filtration of amino salicylic acid isoniazid; the organic solvent as the number of carbon atoms is less than or equal to 6 of the organic ester. The invention adopts the simple and convenient technological condition, and realizes the preparation of salicylic acid isoniazid in a water and ester two-phase solvent system with low cost and high efficiency. The content of isoniazid which is prepared by the method is higher than 99%, and the appearance of the crystal is good, the color is positive, and the stability is good. The method has the advantages of less operation unit, simple process, short time consuming, low production cost, environmental protection, simple operation, easy control and short time consuming, and is suitable for industrial production of isoniazid.
【技术实现步骤摘要】
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】本专利技术涉及化学制药
,具体而言,本专利技术涉及对氨基水杨酸异烟肼的制备方法。【
技术介绍
】对氨基水杨酸异烟肼的化学名为4-吡啶甲酰肼-4-氨基水杨酸,通用名为帕司烟肼,别名为百生肼,化学式为C13H14O4N4,结构式为:
【技术保护点】
对氨基水杨酸异烟肼的制备方法,其步骤为:1)分别量取水和有机溶剂,混合;将对氨基水杨酸和异烟肼加入到水和有机溶剂的溶媒中,加热搅拌;2)冷却养晶,过滤得对氨基水杨酸异烟肼;所述有机溶剂为碳原子数小于或等于6的有机酯类。
【技术特征摘要】
1.对氨基水杨酸异烟肼的制备方法,其步骤为: 1)分别量取水和有机溶剂,混合;将对氨基水杨酸和异烟肼加入到水和有机溶剂的溶媒中,加热搅拌; 2)冷却养晶,过滤得对氨基水杨酸异烟肼; 所述有机溶剂为碳原子数小于或等于6的有机酯类。2.根据权利要求1所述的对氨基水杨酸异烟肼的制备方法,其特征在于所述水选自饮用水、纯化水或注射用水。3.根据权利要求1或2所述的对氨基水杨酸异烟肼的制备方法,其特征在于所述水的用量,以水与对氨基水杨酸异烟肼按体积/重量比计算为2~10L/lkg。4.根据权利要求3所述的对氨基水杨酸异烟肼的制备方法,其特征在于所述水的用量,以水与对氨基水杨酸异烟肼按体积/重量比为4~7L/lkg。5.根据权利要求1所述的对氨基水杨酸异烟肼的制备方法,其特征在于所述有机溶剂选自乙酸乙酯、乙酸甲酯、乙酸丙酯或甲酸乙酯,为其中的一种或它们任意比例的混合物。6.根据权利要求1或5所述...
【专利技术属性】
技术研发人员:金国有,姚柳端,朱艺基,林立权,张传君,
申请(专利权)人:广州白云山制药股份有限公司广州白云山化学制药厂,
类型:发明
国别省市:
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