The present invention discloses use of antagonists of a CJun N-terminal kinase signal pathway, preparation of a composition for inhibiting the generation of amyloid protein. The present invention also discloses a small RNA molecule for inhibiting amyloid protein production. The inventor for the first time found that oxidative stress agents could promote the activation of gamma secretase by activating the C Jun N-terminal kinase signaling pathway, resulting in the production of amyloid. Therefore, new drug targets for neurodegenerative diseases can be developed based on the findings.
【技术实现步骤摘要】
【技术保护点】
一种c-Jun氨基末端激酶信号通路的拮抗剂的用途,其特征在于,用于制备抑制淀粉样蛋白产生的组合物。
【技术特征摘要】
【专利技术属性】
技术研发人员:景乃禾,沈承勇,陈永峰,
申请(专利权)人:中国科学院上海生命科学研究院,
类型:发明
国别省市:31[中国|上海]
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