The present invention discloses use of antagonists of a CJun N-terminal kinase signal pathway, preparation of a composition for inhibiting the generation of amyloid protein. The present invention also discloses a small RNA molecule for inhibiting amyloid protein production. The inventor for the first time found that oxidative stress agents could promote the activation of gamma secretase by activating the C Jun N-terminal kinase signaling pathway, resulting in the production of amyloid. Therefore, new drug targets for neurodegenerative diseases can be developed based on the findings.
【技术实现步骤摘要】
【技术保护点】
一种ｃ－Ｊｕｎ氨基末端激酶信号通路的拮抗剂的用途，其特征在于，用于制备抑制淀粉样蛋白产生的组合物。
【技术特征摘要】
【专利技术属性】
技术研发人员：景乃禾，沈承勇，陈永峰，
申请(专利权)人：中国科学院上海生命科学研究院，
类型：发明
国别省市：31[中国|上海]
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