黄酮苷类化合物在制备治疗疟疾的药物中应用制造技术

本发明专利技术提供了一种黄酮苷类化合物在制备治疗疟疾的药物中应用，尤其是在制备治疗由疟原虫引起的疟疾的药物中应用。所述黄酮苷类化合物具有以下结构通式之一种：式中Ｒ１为香豆酰基、反式香豆酰基或咖啡酰基；Ｒ２为香豆酰基、反式香豆酰基、咖啡酰基或为氢。试验表明，该黄酮苷类化合物与ＦＰ－２蛋白有明显的结合明显的作用。因此，可用于制备治疗疟疾的药物组合物。它含有黄酮苷类化合物活性成分和药学上可以接受的载体，活性成分在药物组合物中的重量含量为０．１－９９．５％。药物剂型可以是片剂、颗粒剂、胶囊、水或油悬浮剂、糖浆、注射液、或悬浮剂等。

Application of flavone glycoside compound in preparing medicine for treating malaria

The present invention provides the use of a flavonoid glycoside compound in the preparation of a medicament for the treatment of malaria, especially in the preparation of a medicament for the treatment of malaria caused by plasmodium. The flavone glycoside compound has one of the following general structural formula: R1 is a bean acyl group, a trans aromatic acyl group or a coffee acyl; and R2 is a bean acyl group, an anti aromatic acyl bean group, a coffee acyl group or a hydrogen base. The test showed that the flavonoids and FP2 protein has obvious binding effect. Therefore, it can be used for preparing a pharmaceutical composition for treating malaria. It contains a vector of flavonoids active components and pharmaceutically acceptable weight, the content of active component in pharmaceutical compositions for 0.199.5%. The pharmaceutical formulations can be tablets, granules, capsules, water or oil suspensions, syrups, injections, or suspensions.

【技术实现步骤摘要】

【技术保护点】
一种黄酮苷类化合物在制备治疗疟疾的药物中应用，其特征在于所述黄酮苷类化合物具有以下结构通式之一种：　　　　＊＊＊　　　　式中Ｒ↓［１］为香豆酰基、反式香豆酰基或咖啡酰基；Ｒ↓［２］为香豆酰基、反式香豆酰基、咖啡酰基或为氢。

【技术特征摘要】

【专利技术属性】
技术研发人员：张卫东，黄瑾，单磊，李洪林，王立言，张寿德，卢伟强，苏娟，陈瞳，
申请(专利权)人：中国人民解放军第二军医大学，华东理工大学，
类型：发明
国别省市：31[]