The invention provides a Centella asiatica total glycoside liposome and a preparation method thereof, which belongs to the technical field of medicine and drug manufacture. The extremities of Centella asiatica total glycosides include lecithin, cholesterol, Centella asiatica total glycosides and ultrapure water, and the mass ratio of lecithin to cholesterol is 4 8:1; the mass ratio of lecithin to Centella asiatica total glycosides is 20 40:1; and the volume ratio of organic phase to water phase is 5 7:1. Methods: lecithin and cholesterol were selected according to a certain proportion, then lecithin and cholesterol were dissolved in chloroform, then added the water solution of Centella asiatica total glucoside, ice water bath ultrasound was formed, the homogeneous emulsion was formed, the emulsion was rotated and evaporated to form gel state, and an appropriate amount of ultra pure water solution was added, and the gel was dropped for 1 hours, and the ice water bath ultrasonic was removed. The invention has good transdermal performance and sustained release effect, can effectively act on the lesion for a long time, and achieves better therapeutic effect.
【技术实现步骤摘要】
一种积雪草总苷脂质体及其制备方法
本专利技术属于药品及药品制造
,特别涉及一种积雪草总苷脂质体及其制备方法。
技术介绍
积雪草总苷(centellatotalglucosides,CTG)是伞形科植物积雪草的提取物,有效成分为三萜型皂苷及其衍生物类,其中以积雪草苷、羟基积雪草苷的含量最高,活性最强。现代药理研究表明:CTG不仅能够促进细胞生长,加速伤口愈合,修复皮肤损伤,还具有抗氧化,抗溃疡、消炎等作用。临床上常用于手术创伤、烧伤,增生性疤痕等疾病的治疗。但由于CTG中多为极性大分子,不容易透过皮肤表皮到达病变部位,单纯的促渗不能完全达到治疗疾病的目的。将药物包封于脂质体中,不仅可以发挥良好的促透作用,还可使药物尽可能少的进入血液循环,集中于皮肤病灶,形成药物贮库,缓释药物,是理想化的皮肤局部给药载体。与普通外用制剂相比,脂质体可以增加药物的治疗指数,减少给药次数及剂量,提高患者的顺应性。因此有必要优化CTG脂质体的制备工艺,并对其理化性质及体外透皮特性进行考察。
技术实现思路
针对积雪草总苷脂质体的处方优化问题,本专利技术在前期工作研究的基础上,通过采用单因素结合Box-Behnken效应面法优化积雪草总苷脂质体的制备工艺。一种积雪草总苷脂质体,包括卵磷脂、胆固醇、积雪草总苷和超纯水,且卵磷脂与胆固醇的质量比为4-8﹕1;卵磷脂与积雪草总苷的质量比为20-40:1;有机相与水相的体积比为5-7﹕1。进一步的,卵磷脂与胆固醇的质量比4﹕1,卵磷脂与积雪草总苷的质量比23.22﹕1,有机相与水相的体积比7﹕1。一种积雪草总苷脂质体的制备方法,包括以下步骤: ...
【技术保护点】
1.一种积雪草总苷脂质体,其特征在于:包括卵磷脂、胆固醇、积雪草总苷和超纯水,且卵磷脂与胆固醇的质量比为4‑8﹕1;卵磷脂与积雪草总苷的质量比为20‑40∶1;有机相与水相的体积比为5‑7∶1。
【技术特征摘要】
1.一种积雪草总苷脂质体,其特征在于:包括卵磷脂、胆固醇、积雪草总苷和超纯水,且卵磷脂与胆固醇的质量比为4-8﹕1;卵磷脂与积雪草总苷的质量比为20-40∶1;有机相与水相的体积比为5-7∶1。2.根据权利要求1所述的一种积雪草总苷脂质体,其特征在于:卵磷脂与胆固醇的质量比4﹕1,卵磷脂与积雪草总苷的质量比23.22﹕1,有机相与水相的体积比7﹕1。3.一种积雪草总苷脂质体的...
【专利技术属性】
技术研发人员:杨荣平,
申请(专利权)人:西南大学,重庆悦花越有生物科技有限公司,
类型:发明
国别省市:重庆,50
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