The present invention provides a class of substituted five membered heterocyclic compounds and pharmaceutically acceptable salts, esters, solvates, metal complexes, or prodrugs having the same biological activity, as represented by the following general formula. The invention also provides the compounds as a class of glucagon like peptide 1 receptor (GLP 1R) signal transduction synergist (Positive modulator) and the use in the prevention or treatment of metabolic diseases (including but not limited to type 2 diabetes, insulin resistance and obesity, etc.) cardiovascular disease and neurodegenerative diseases such as Alzheimer's disease [(Alzheimer 's Disease, AD), also known as Alzheimer's disease (Alzheimer s dementia)] in the application.
【技术实现步骤摘要】
【技术保护点】
由以下通式（式１）表示的一类取代五元杂环化合物或其药物学上可接受的盐、酯、溶剂化物、金属配合物、或者与其具有相同生物活性的前药： ［式１］ ＊＊＊ 其中Ｙ为Ｏ或Ｓ； Ｒ↓［１］、Ｒ↓［２］各自独立地为Ｈ、乙酰基、苯基或＊ ＊＊、苄基或＊＊＊、苯乙基、二苯甲基、萘基、或者取代或未取代的Ｃ１－Ｃ１０的烷基；其中Ｘ↓［１］、Ｘ↓［２］、Ｘ↓［３］各自独立地为Ｎ或ＣＨ；Ｒ↓［６］、Ｒ↓［７］、Ｒ↓［８］、Ｒ↓［９］各自独立地为Ｈ、Ｆ、Ｃｌ、Ｂｒ、ＣＦ↓［３］、甲酸甲酯基、苯基、Ｃ１－Ｃ６的烷基、Ｃ１－Ｃ６的烷胺基或烷氧基； Ｒ↓［３］、Ｒ↓［４...
【技术特征摘要】
【专利技术属性】
技术研发人员：王明伟，苑芸芸，周玲，安德鲁A杨，张翱，高林东，苏昊然，吴茜茜，汪佳，王菊，
申请(专利权)人：国家新药筛选中心，中国科学院上海药物研究所，
类型：发明
国别省市：31[中国|上海]
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