【技术实现步骤摘要】
用于复杂亲缘关系分析的分子标记组合、引物组、试剂盒及分析方法
[0001]本专利技术涉及个体身份识别
，尤其是涉及一种用于复杂亲缘关系分析的分子标记组合、引物组、试剂盒及分析方法。
技术介绍
[0002]复杂亲缘关系分析是法医物证学学科发展的重要研究方向，在司法实践、刑事侦查、灾害遇难者身份识别等领域具有重大社会需求。目前，亲子鉴定和全同胞鉴定均已发展得比较成熟，但对于更远的复杂亲缘关系，如二级、三级、四级亲缘关系，仍然缺少有效的解决方案。因为两个个体之间的亲缘关系越远，所共享的等位基因越少，需要检测的遗传标记就越多，鉴定难度也越大。现有检测方法系统效能的不足和生物检材的降解是导致复杂亲缘关系推断困难的主要原因。
[0003]近年来，单核苷酸多态性(single nucleotide polymorphism，SNP)成为备受关注的新型短片段遗传标记，在亲缘关系分析领域展现出了巨大潜力。比起传统的STR遗传标记，它们的扩增片段短，在降解检材分析中具有独特优势；突变率远低于STR，约为10
‑8；不受滑脱峰的干扰，更易于分型分析。虽然单个二等位遗传标记的鉴定效力较低，但在人类基因组中大约包括1500万个SNP，可用的SNP数量非常庞大，通过复合扩增和高通量测序技术，增加检测基因座的数量，同样可达到较高的亲缘鉴定效力。基于高通量测序平台，构建多重复合扩增系统，能够同时检测大量STR和SNP短片段遗传标记，增强对亲缘关系的鉴定效力。
[0004]目前，市场上身份识别效力最强的美国商品化检测试剂...
【技术保护点】
【技术特征摘要】
1.一种用于复杂亲缘关系分析的分子标记组合，其特征在于，包括以下部分或全部SNP位点：rs1490413、rs655839、rs12124007、rs2762888、rs563835、rs11261001、rs2153194、rs7515666、rs10916686、rs6671407、rs10799639、rs4654788、rs12753744、rs4659356、rs6672165、rs1080110、rs35621971、rs271370、rs6690155、rs34223420、rs194663、rs6703838、rs4653277、rs6600334、rs882000、rs942761、rs11206607、rs10158668、rs7536346、rs1601238、rs4660242、rs2934857、rs12097081、rs511390、rs12041298、rs857044、rs10159308、rs11207579、rs66474724、rs10158452、rs10889366、rs12129593、rs1496028、rs7415829、rs747253、rs7522980、rs495581、rs12031454、rs4650613、rs34140910、rs111825012、rs3852315、rs3813608、rs753504、rs12070155、rs6658587、rs12022152、rs6678668、rs1192406、rs2770186、rs481214、rs957334、rs4245671、rs10747480、rs2030342、rs6660105、rs4620590、rs12143205、rs4908314、rs11166487、rs6676334、rs1361814、rs10857986、rs7521423、rs6537836、rs1475405、rs815125、rs1707111、rs826410、rs4659061、rs2493793、rs6428779、rs1342700、rs7521171、rs10399679、rs6667139、rs11583485、rs7523883、rs9651054、rs1889011、rs10797001、rs11264984、rs560681、rs4656736、rs36112567、rs2795288、rs6425218、rs964769、rs7526528、rs766021、rs6425495、rs2793802、rs9970363、rs9425558、rs4651259、rs7524832、rs6413547、rs2011111、rs4534384、rs10922445、rs10920388、rs814974、rs1246716、rs2785781、rs10754133、rs7548148、rs10801627、rs6427769、rs76015651、rs7531238、rs7549999、rs7546330、rs2796373、rs9660813、rs1621023、rs7548258、rs4436393、rs7525379、rs3106405、rs4655322、rs6683507、rs12049223、rs10863378、rs28694430、rs6688793、rs756245、rs6541181、rs10495172、rs34557512、rs2609346、rs6686240、rs12139725、rs1294331、rs6428980、rs10495407、rs789375、rs2820208、rs60790494、rs12138491、rs891700、rs1809313、rs1610397、rs12128355、rs4660080、rs4658563、rs4658404、rs4658827、rs1413212、rs1931054、rs6429377、rs616865、rs9787319、rs10927350、rs3007313、rs1779970、rs10737809、rs6668460、rs876724、rs12472197、rs6751030、rs7595988、rs28435671、rs2572150、rs1019320、rs883853、rs1109037、rs10929646、rs1728144、rs2056152、rs807582、rs7595922、rs62124612、rs4487059、rs60209665、rs2681024、rs1545257、rs12714232、rs13391574、rs160805、rs11124431、rs4670512、rs2949084、rs11883493、rs10169654、rs1441234、rs10865178、rs4602260、rs6730971、rs2004578、rs10188427、rs4952723、rs532628、rs1517027、rs558368、rs7607215、rs2346877、rs4452203、rs36191440、rs11673995、rs11125467、rs2194408、rs1521936、rs4671216、rs6730195、rs10175257、rs2139787、rs6737858、rs2441381、rs4672484、rs641809、rs6755464、rs6725366、rs7595007、rs1239069、rs2177098、rs440752、rs2193694、rs2711422、rs11688051、rs7595080、rs3112989、rs62155069、rs58003373、rs7568152、rs6755684、rs13012743、rs11897678、rs77043467、rs2708919、rs4848324、rs175775、rs12621381、rs57391290、rs1349459、rs747834、rs56388161、rs6721402、rs980941、rs993934、rs58172804、rs10205772、rs67211175、rs7567299、rs11677331、rs11891266、rs837854、rs2704563、rs2464779、rs7586789、
rs272137、rs11692739、rs985385、rs12466623、rs1960979、rs6718034、rs10199399、rs10165615、rs56403477、rs1358411、rs16856956、rs12477181、rs1474011、rs12691748、rs4662490、rs1424951、rs330625、rs16828958、rs7349449、rs1427398、rs13409316、rs16839896、rs4131815、rs2389840、rs7590269、rs1446796、rs6738158、rs13001144、rs10176777、rs6739014、rs12997453、rs4490144、rs7574189、rs10184204、rs4595929、rs2033137、rs2059360、rs10206144、rs4667173、rs12998431、rs4853616、rs2357154、rs6716963、rs2667153、rs7595339、rs6730991、rs1879876、rs4675391、rs10208393、rs860278、rs7580755、rs9973315、rs13003842、rs7588951、rs12990703、rs6707503、rs1355204、rs1437917、rs13413336、rs1975326、rs9784109、rs13032829、rs12162346、rs56878069、rs6436703、rs10211246、rs4973388、rs2194551、rs6736679、rs4972990、rs10933377、rs1190417、rs11675479、rs250949、rs11683231、rs9287579、rs6742844、rs34234682、rs11903522、rs28364850、rs4663810、rs7581625、rs907100、rs4241231、rs4854005、rs4276057、rs66492261、rs6442890、rs1357617、rs11128510、rs6780577、rs7617084、rs2874666、rs1488401、rs9822774、rs6773522、rs56254444、rs6767324、rs1948153、rs378324、rs6775085、rs9850082、rs6776735、rs1550158、rs4419364、rs842264、rs1375633、rs980261、rs822766、rs4484143、rs6764839、rs3913110、rs7635117、rs12632002、rs1395165、rs11711650、rs4364205、rs11129617、rs4600777、rs1507866、rs9713122、rs13065560、rs7640228、rs1668252、rs9868951、rs2364306、rs930632、rs13100757、rs781296、rs17140815、rs9816648、rs9845708、rs58654499、rs1973350、rs11128315、rs1905094、rs7610547、rs1526729、rs9836455、rs9812243、rs9841163、rs4583604、rs9857462、rs9990211、rs34103961、rs1514441、rs12490217、rs2448984、rs793450、rs1004115、rs1616007、rs2399332、rs13088866、rs6800648、rs2133628、rs9647328、rs6438278、rs6772008、rs60473817、rs2668339、rs655037、rs13318260、rs12496521、rs28457046、rs11719293、rs2712405、rs13059321、rs1358020、rs6771993、rs6772753、rs1429763、rs2724711、rs2028994、rs4683627、rs13060437、rs6809194、rs9837387、rs13074756、rs4600855、rs7635971、rs62286615、rs7651941、rs308689、rs2405034、rs1387007、rs150212、rs6548357、rs7428595、rs61796619、rs9882428、rs2337368、rs9290743、rs3109398、rs6793734、rs28546070、rs6808883、rs6809601、rs6802330、rs6810075、rs11713648、rs1452196、rs62280066、rs12631700、rs6803890、rs12634190、rs1355366、rs3104147、rs6795942、rs2593885、rs6444724、rs12635616、rs11719062、rs6437432、rs7622435、rs9817463、rs2046361、rs756416、rs10000201、rs16889619、rs4698248、rs218800、rs10002394、rs7667101、rs10516308、rs1610064、rs4599412、rs207310、rs4631026、rs13132892、rs11722116、rs28502745、rs3857105、rs35096275、rs28430366、rs6823021、rs7688845、rs925470、rs2063527、rs6829274、rs4359913、rs10007257、rs11735393、rs2046640、rs34819212、rs10015679、rs2010717、rs28765997、rs6842566、rs10017637、rs279844、rs4695332、rs4320113、rs6850695、rs6840739、rs4543192、rs1824965、rs10024730、rs6850123、rs4865233、rs11930316、rs2412881、rs2662840、rs7693572、rs9991718、rs13134004、rs4557293、rs1580554、rs34789399、rs11131623、rs7672779、rs13126839、rs356342、rs61618891、rs28744454、
rs6814427、rs10018277、rs35784055、rs4694600、rs7691570、rs10518129、rs6847782、rs12644940、rs2868183、rs4367163、rs28614066、rs6830322、rs7658573、rs6531968、rs6532990、rs456734、rs57692580、rs6533256、rs55733895、rs9996734、rs7655123、rs56912199、rs2595112、rs2129980、rs200765729、rs7691241、rs4469076、rs6849622、rs7696214、rs72676244、rs7664153、rs28734896、rs1808022、rs12511880、rs28428468、rs6822124、rs11938508、rs7682481、rs10518426、rs7675705、rs9784420、rs10028564、rs1816301、rs13112008、rs7695040、rs11099000、rs1489452、rs395528、rs12511875、rs13118688、rs10008697、rs17702495、rs11099440、rs1900168、rs12711385、rs4956408、rs11100735、rs9942259、rs7688003、rs1429117、rs10017483、rs7663914、rs3846245、rs7679672、rs11100423、rs6855760、rs7375466、rs4381999、rs4314235、rs13109075、rs2319259、rs1120854、rs6811238、rs6841704、rs4540018、rs10019203、rs4456939、rs4690382、rs13150443、rs1598577、rs55743015、rs10520392、rs2702387、rs393318、rs11942346、rs6552345、rs2605063、rs2878001、rs10866233、rs36029731、rs2309256、rs7659432、rs2546591、rs2613049、rs1916112、rs11930005、rs35563562、rs6823305、rs2309550、rs4862122、rs2603343、rs6848055、rs7670109、rs3121384、rs7670338、rs12511470、rs4862626、rs370485、rs1895844、rs112834401、rs4371695、rs34886016、rs2376985、rs6828125、rs1979255、rs4975532、rs1875194、rs7734041、rs13187481、rs2019736、rs13173005、rs2962607、rs717302、rs1215682、rs7730400、rs860439、rs10052458、rs729028、rs526025、rs10780104、rs12656335、rs13361532、rs1598734、rs271399、rs6555445、rs1503316、rs1506135、rs1580930、rs6871121、rs314732、rs13435917、rs1995365、rs6874191、rs10035874、rs392421、rs7719946、rs2592029、rs159606、rs526047、rs7737270、rs2967004、rs2635654、rs13165720、rs10045056、rs187464、rs1835055、rs6885388、rs4867005、rs6895028、rs1921093、rs111236030、rs2937561、rs2963973、rs6450913、rs12656497、rs272735、rs7709261、rs12652037、rs2468499、rs10214103、rs181328、rs6884830、rs2910872、rs6886513、rs7714518、rs153665、rs256088、rs11740254、rs346097、rs253230、rs12516459、rs249479、rs26337、rs2637130、rs188059、rs1971399、rs1217806、rs35062883、rs283596、rs3106282、rs7730344、rs34268756、rs34048043、rs6888906、rs4572979、rs13182115、rs1352736、rs2434282、rs6863166、rs11739837、rs10805810、rs6864109、rs2657001、rs4260646、rs13176141、rs13168021、rs7726549、rs10942376、rs2118734、rs1422117、rs12520179、rs323811、rs12652212、rs2972945、rs6867534、rs6885729、rs10780128、rs200650111、rs11960474、rs1161317、rs2203159、rs4596351、rs4703278、rs2135050、rs4566775、rs34566010、rs7719528、rs154215、rs12656652、rs13176379、rs10056970、rs341290、rs2128313、rs7732200、rs4596374、rs2964564、rs256954、rs2416419、rs2964662、rs6886797、rs2624482、rs6883679、rs246754、rs4509077、rs13173424、rs248158、rs4976516、rs13182883、rs7733403、rs427148、rs185437、rs822472、rs6878263、rs7736621、rs13161359、rs6876764、rs9313993、rs951699、rs1979008、rs2112708、rs13186702、rs2249080、rs7725699、rs6893242、rs10039121、rs153752、rs34003080、rs7734339、rs356056、rs12521156、rs34692042、rs251934、rs2544738、rs2963832、
rs4868645、rs62397663、rs10074870、rs338882、rs6896886、rs13183809、rs13185786、rs866049、rs13218440、rs9349152、rs12209898、rs1413513、rs9464704、rs2092733、rs9297002、rs1745069、rs6459557、rs9396818、rs7753875、rs1033955、rs1202285、rs653254、rs9350245、rs4712701、rs199062、rs197999、rs1535985、rs1277137、rs1011665、rs2517533、rs3130456、rs6930376、rs2442743、rs3104407、rs9276820、rs9277904、rs2495957、rs1873255、rs4713884、rs6930083、rs7741421、rs1331123、rs11968347、rs2067898、rs2206271、rs2465010、rs6930519、rs2493193、rs9382544、rs73464635、rs2639386、rs1779748、rs9354379、rs1475329、rs9363656、rs4410715、rs1083340、rs6930785、rs9446440、rs1854355、rs186849878、rs1777793、rs10455344、rs9294112、rs6941828、rs7750052、rs4706140、rs1321620、rs1336071、rs58690526、rs3923405、rs330832、rs6938836、rs2841309、rs6934888、rs6571046、rs9399776、rs35185856、rs6935029、rs6930883、rs9499840、rs67268824、rs1078227、rs9480740、rs7771446、rs9401327、rs6919681、rs524613、rs476552、rs1155003、rs4897353、rs9375740、rs1848410、rs6915839、rs9493389、rs9385697、rs7356883、rs1890391、rs9373179、rs9321601、rs9373197、rs4398760、rs4391279、rs4072064、rs12203051、rs479916、rs208720、rs7772879、rs9371391、rs9384516、rs214955、rs2250632、rs685341、rs11756346、rs1344161、rs7763080、rs9384355、rs2883612、rs4072635、rs6455586、rs2171780、rs9347489、rs1040640、rs9365640、rs1472343、rs727811、rs6927286、rs4128602、rs6926333、rs4521564、rs28537136、rs597436、rs9364229、rs2181943、rs6605527、rs59793087、rs719960、rs752576、rs36152679、rs36187275、rs10950451、rs11976390、rs2117347、rs10952199、rs1639046、rs1713913、rs7798896、rs1917691、rs6955448、rs917118、rs10951565、rs7790296、rs6463668、rs6963280、rs6967307、rs1285374、rs10276221、rs161089、rs13234039、rs10234570、rs1120451、rs36014865、rs1440018、rs12112961、rs10950509、rs2389540、rs10276865、rs6947332、rs42100、rs10248727、rs850134、rs7791182、rs56072028、rs10263892、rs10265222、rs10480131、rs11763394、rs940347、rs6961734、rs2190329、rs6960730、rs2190339、rs2583877、rs765108、rs28499488、rs1589896、rs6975610、rs10229059、rs11761091、rs6947143、rs9791574、rs10250966、rs59324037、rs1722688、rs2552055、rs10246512、rs7804465、rs9649758、rs17135887、rs526461、rs4418307、rs1828792、rs5013285、rs11765075、rs55918616、rs7803698、rs2530420、rs11978860、rs10452727、rs41860、rs11514693、rs13221602、rs4484568、rs4717863、rs10281928、rs2888830、rs10953098、rs6976724、rs43052、rs56323429、rs12056236、rs1234566、rs7800912、rs6942831、rs4599742、rs6976158、rs4727668、rs2395931、rs10235968、rs6949987、rs138501054、rs2528681、rs10249632、rs7810206、rs10273352、rs12668510、rs6959362、rs6968432、rs79913611、rs712735、rs10808243、rs2398799、rs12672016、rs321198、rs2465922、rs6960172、rs9648842、rs4726732、rs764295、rs2140517、rs28785521、rs10259040、rs55692710、rs1404862、rs2628708、rs2888631、rs6974171、rs62479828、rs4726116、rs2014611、rs4726238、rs1722933、rs3110889、rs57524960、rs446938、rs10260348、rs150108012、rs6979851、rs4716952、rs6969259、rs737681、rs10270019、rs1558426、rs1182419、
rs13221375、rs763869、rs341668、rs4581074、rs1526347、rs34032427、rs11992775、rs2816520、rs28731775、rs9693942、rs2977793、rs2001662...
【专利技术属性】
技术研发人员：王升启，张庆珍，杨森，周喆，
申请(专利权)人：中国人民解放军军事科学院军事医学研究院，
类型：发明
国别省市：
还没有人留言评论。发表了对其他浏览者有用的留言会获得科技券。