The present invention discloses a genetic marker combination and detection method for individual identification and / or paternity identification of human body. The present invention through a variety of group whole genome SNPs unbiased scanning combined SNPs loci were widely used in many races, from the 25580678 SNPs loci in genome wide screening 116 in 37 populations from different regions of the world have higher allele frequency and low genetic differences, independent autosomal SNPs sites and 12 have higher allele frequency and low genetic differences, independent of each other in 37 populations from different regions of the world in the X chromosome SNPs loci. The invention of the SNPs locus in combination with the existing commercial kit compared with a broader variety of family adaptability, and the cumulative probability of individual recognition and cumulative probability of exclusion were significantly better than the commercial kit, the detection results more accurate, with great application prospect.
【技术实现步骤摘要】
用于人体个体识别和/或亲权鉴定的遗传标记及其检测方法和试剂盒
本专利技术属于法医遗传学
更具体地，涉及一种用于人体个体识别和/或亲权鉴定的遗传标记及其检测方法和试剂盒。
技术介绍
DNA证据被广泛应用于人体个体识别和亲权鉴定中，在刑事诉讼、民法案件、灾难性事故处理、科学研究等领域发挥关键的科学证据作用。所谓DNA证据即不同个体的染色体上的遗传标记基因型是否满足法医遗传学要求。目前DNA鉴定主要是检验相互独立遗传的十三至二十多个不等的短串联重复片段(Shorttandemrepeats,STRs)，被称为第二代遗传标记。第三代遗传标记—单核苷酸多态性(Singlenucleotidepolymorphisms,SNPs)已开始被应用于DNA鉴定。随着基因组学理论和DNA测序技术的进一步发展，SNPs被发现具有诸多STRs所不具备的特点，使其在法医学应用中更具优势，比如：(1)在全基因组范围内具有更高的分布密度，具有远多于STRs的候选位点；(2)SNPs为单碱基变异位点，远远短于数十甚至上百个碱基长度的STRs，使得其PCR扩增片段可以更短，对于高度降解检材...
【技术保护点】
用于人体个体识别的遗传标记，其特征在于，包括116个常染色体SNPs位点及12个X染色体SNPs位点：rs2662800、rs11938834、rs10852588、rs2624459、rs17533、rs163192、rs4644087、rs12934069、rs628221、rs1293288、rs10911093、rs1538197、rs9308179、rs11914834、rs1078226、rs6955484、rs6136874、rs4239719、rs7127767、rs2826399、rs1354147、rs508485、rs4835587、rs2895309...
【技术特征摘要】
1.用于人体个体识别的遗传标记，其特征在于，包括116个常染色体SNPs位点及12个X染色体SNPs位点：rs2662800、rs11938834、rs10852588、rs2624459、rs17533、rs163192、rs4644087、rs12934069、rs628221、rs1293288、rs10911093、rs1538197、rs9308179、rs11914834、rs1078226、rs6955484、rs6136874、rs4239719、rs7127767、rs2826399、rs1354147、rs508485、rs4835587、rs2895309、rs3010325、rs11785007、rs4539869、rs564060、rs6962246、rs7710068、rs4582363、rs447205、rs471234、rs4708582、rs2941011、rs879628、rs10451160、rs7728549、rs397728、rs10865186、rs3790955、rs825411、rs4773029、rs974110、rs623052、rs2127995、rs4750494、rs1176842、rs9864924、rs4487849、rs4942242、rs2267708、rs6989344、rs9504195、rs980346、rs2380437、rs6694450、rs4449484、rs4469483、rs4722897、rs4790519、rs4607417、rs530913、rs3850890、rs9542974、rs9544749、rs4942486、rs6073336、rs2024408、rs4282012、rs9432040、rs1574275、rs9364939、rs7582470、rs937002、rs12694624、rs208869、rs1193735、rs12819145、rs271397、rs7142477、rs11655774、rs12925084、rs10518608、rs7607215、rs2459110、rs2570703、rs431951、rs12605006、rs9672254、rs9297731、rs12350076、rs10256874、rs7167880、rs560476、rs7561460、rs783622、rs10783100、rs2425427、rs1971391、rs1445688、rs11590681、rs722847、rs6460078、rs10503926、rs530022、rs1012515、rs4701737、rs1404719、rs6431272、rs7326317、rs10490047、rs7983579、rs2831350、rs1464095、rs7710223、rs11159161、rs1807986、rs5916698、rs2071178、rs5985930、rs6520279、rs5905669、rs3128264、rs5966755、rs17332040、rs5907677、rs12843815。2.根据权利要求1所述的遗传标记，其特征在于，所述128个SNPs位点中，有34个可被其它1个或多个SNPs位点替代；所述34个SNPs及对应的可替代的SNPs如下所示：rs10911093可替代为rs10797785或rs9787011；rs2895309可替代为rs2399091；rs271397可替代为rs9451；rs1078226可替代为rs2354159或rs3127637；rs1012515可替代为rs9389449、rs3799480或rs1498553；rs6460078可替代为rs10949838；rs7127767可替代为rs12...
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