The invention discloses the application of a polypeptide and polypeptide composition in the treatment of colon cancer, belonging to the field of biomedicine. Specifically, it is based on the characteristics of tumorigenesis and treatment difficulties. The polypeptide sequence is invented through the anti-tumorigenic treatment pathway, which proves that it has the application value of anti-tumour. The polypeptide sequence was synthesized by biosynthetic technology. The amino acid sequence of the polypeptide sequence was shown in SEQ ID NO. 1. 3, and the polypeptide composition included the above three sequences. Then the anti-cancer function of the polypeptide and polypeptide compositions is studied. Through the treatment of the polypeptide/polypeptide compositions, the polypeptide and polypeptide compositions have the important anti-cancer function of inhibiting the activity of tumor cells and inhibiting the growth of mouse tumorigenic model. The invention provides experimental basis for the development of new targets for cancer treatment, and has very important development and application prospect for the clinical treatment of cancer.
【技术实现步骤摘要】
一种多肽、多肽组合物在治疗结肠癌中的应用
本专利技术涉及生物医药
,具体地说,是一种通过与β-catenin有效结合并促其正常降解,从而达到抑制肿瘤生长,治疗结肠癌的小分子多肽、多肽组合物及其应用。
技术介绍
结肠癌(cancerofcolon)是西欧、北美等发达国家最常见的恶性肿瘤,也是我国九大常见恶性肿瘤之一。在过去30多年的时间里,包括我国在内的多数国家或地区结肠癌发病率呈上升趋势。在我国因结肠癌死亡者,男性居恶性肿瘤死亡的第5位,女性居第6位。从流行病学的观点看,结肠癌的发病与社会环境、生活方式(尤其是饮食习惯、缺乏体力活动)、遗传因素有关,年龄、结直肠息肉史、溃疡性结肠炎及胆囊切除史也是结肠癌的高危因素,但总体而言,结肠癌的病因并非很清楚。APC基因是由Herrera于1986年对1例格德纳综合征(葡萄糖注射液)患者进行细胞遗传学研究时发现的一个新的抑癌基因。Groden等于1991年从结肠癌中首先克隆到这一基因,并正式命名为DP2,5或腺瘤样结肠息肉易感基因(AdenomatousPolyposisColi)。Groden和Kinzler等应用PCR技术和特异cDNA探针分析,确定DP2,5基因即为APC基因。早期研究发现该基因不仅与家族性结肠腺瘤息肉病(FAP)有关,后发现其在散发性大肠癌的发生中也起着重要作用。Chop等应用免疫沉淀技术也证实大肠癌组织中缺乏野生型APC蛋白,提示APC蛋白缺失表达可能与大肠癌的发生与演进密切相关。APC基因在FAP及散发性大肠癌(SCRC)中所显示生殖细胞与体细胞突变谱的相似性,提示APC基因参与这两 ...
【技术保护点】
1.一种多肽,其特征在于,所述多肽包含以下任意一条序列:SEQ ID NO.1‑3所示的氨基酸序列;SEQ ID NO.1:Glu Asp Asp Lys Pro Thr Asn Tyr Ser Glu Arg Tyr Ser Glu Glu Lys Arg Lys Arg Lys Arg Lys Arg LysSEQ ID NO.2:Glu Leu Asp Thr Pro Ile Asn Tyr Ser Leu Lys Tyr Ser Asp Glu Lys Arg Lys Arg Lys Arg Lys Arg LysSEQ ID NO.3:Glu Glu Glu Arg Pro Thr Asn Tyr Ser Ile Lys Tyr Asn Glu Glu Lys Arg Lys Arg Lys Arg Lys Arg Lys。
【技术特征摘要】
1.一种多肽,其特征在于,所述多肽包含以下任意一条序列:SEQIDNO.1-3所示的氨基酸序列;SEQIDNO.1:GluAspAspLysProThrAsnTyrSerGluArgTyrSerGluGluLysArgLysArgLysArgLysArgLysSEQIDNO.2:GluLeuAspThrProIleAsnTyrSerLeuLysTyrSerAspGluLysArgLysArgLysArgLysArg...
【专利技术属性】
技术研发人员:刘红林,刘海林,刘星云,李玥熹,程牛亮,牛勃,覃秀桃,王晓霞,
申请(专利权)人:山西医科大学,
类型:发明
国别省市:山西,14
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