The invention relates to a crystallization form of free alkali of imidazole isoindole derivatives and a preparation method thereof. Specifically, the invention relates to the A, B, C, C, D, E, F crystal form of the compound shown in formula (I) of the invention, which is chemically named (S)8209 2 8209 (4 8209 (4 8204 (4 8204 (4 8209 (6 fluflufluflufluflufluflufluflufluflufluflufluflufluflufluflufluflufluflufluflufluflufluflufluflufluflufluflufluflufluflu5H 820imiimidazo [5,1 8209a] isoindindole [5 8209yl) pipiperidindin 8209 1 8209 phenyl) phenyl) 8201H 8201 pyrazole pyrazole 1 ethylethylethylethylethylethylethylethylethylethylethylethylethylethylethylethylThis is the case. The invention also relates to the preparation method of A, B, C, D, E, F crystal forms, their application in pharmaceutical compositions, and the application of A, B, C, D, E, F crystal forms and pharmaceutical compositions in the preparation and treatment of diseases with pathological characteristics of Tryptophan metabolism pathway mediated by IDO. The A, B, C, D, E and F crystal forms of the compounds obtained by the invention have good properties. Stability, low toxicity and low residue of crystalline solvents can be better used in clinical treatment.
【技术实现步骤摘要】
【国外来华专利技术】PCT国内申请,说明书已公开。
【技术保护点】
PCT国内申请,权利要求书已公开。
【技术特征摘要】
【国外来华专利技术】2016.10....
【专利技术属性】
技术研发人员:曹笑立,尤凌峰,肖昌琴,杜振兴,王立坤,
申请(专利权)人:江苏恒瑞医药股份有限公司,上海恒瑞医药有限公司,成都盛迪医药有限公司,
类型:发明
国别省市:江苏,32
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