一组用于近视诊断及右眼柱镜筛查的SNP组合标志物及其应用制造技术

技术编号:33564524 阅读:27 留言:0更新日期:2022-05-26 23:02
本发明专利技术属于生物医药领域,涉及一组用于近视诊断及右眼柱镜筛查的SNP组合标志物及其应用。本发明专利技术利用人工智能方法分析近视眼人群和正常人群SNP位点基因频率存在差异的SNP位点对近视的诊断效能。本发明专利技术的近视诊断模型可有效识别近视人群或存在近视风险的人群。效识别近视人群或存在近视风险的人群。效识别近视人群或存在近视风险的人群。

【技术实现步骤摘要】
一组用于近视诊断及右眼柱镜筛查的SNP组合标志物及其应用


[0001]本专利技术属于生物医药领域,涉及一组用于近视诊断及右眼柱镜筛查的SNP组合标志物及其应用。

技术介绍

[0002]眼科疾病是指发生在眼部区域的疾病,常见眼科疾病有近视、散光、白内障、青光眼、中心浆液性视网膜病变、干眼症、交感性眼炎、夜盲症、弱视、沙眼、糖尿病视网膜病变、结膜炎、老花眼、色盲、视网膜色素变性、视网膜中央动脉阻塞、视网膜脱落、远视、针眼、雪盲症、霰粒肿、飞蚊症等。在调节放松的状态下,平行光线经眼球屈光系统后聚焦在视网膜之前,称为近视。
[0003]屈光度是指屈光不正状态下所产生的度数大小,当屈光度发生时,一般多代表近视、散光、远视或是弱视等临床表现,近视、远视通常为球镜(S),散光为柱镜(C),目前采用等效球镜度数(Spherical Equivalent Refraction,SE)评价屈光度,等效球镜度数=球镜度数+散光度数*1/2。屈光度≤

0.50D可作为近视诊断的循证共识阈值。更具体地,近视的定义是当调节放松时,眼睛的等效球镜本文档来自技高网...

【技术保护点】

【技术特征摘要】
1.一种诊断近视的SNP位点,所述SNP位点包括以下任一组的位点组合:1)rs42688、rs143580489、rs10484690、rs189212243;2)rs12408385、rs2275365、rs374309842、rs77901289、rs147707514、rs143100530、、rs41298993、rs26173、rs26098、rs1353251、rs5867289、rs1494555、rs42688、rs32210、rs143580489、rs1204114、rs10484690、rs118151455、rs201920957、rs189212243、rs117569740、rs2271001、rs185257411、rs698028、rs4923849、rs12904657、rs62037369、rs13337155、rs17223038、rs199667693、rs148965154;3)rs12408385、rs2275365、rs2275360、rs368345074、rs80002732、rs374309842、rs77901289、rs191506876、rs147707514、rs3087649、rs10177030、rs143100530、rs1434087、rs3748962、rs28900693、rs1077827、rs80341144、rs3213930、rs41298993、rs3749584、rs10517195、rs2271924、rs13147012、rs79482316、rs3827497、rs26173、rs26098、rs26107、rs26086、rs1353251、rs5867289、rs1494555、rs42688、rs32210、rs154483、rs7764126、rs13205210、rs143580489、rs1204114、rs10484690、rs118151455、rs200111157、rs113281844、rs201920957、rs79960636、rs112596877、rs117509972、rs189212243、rs74699763、rs2584、rs7023474、rs117569740、rs147367410、rs61748723、rs17849182、rs79735301、rs145978705、rs304494、rs115526095、rs7907476、rs4880361、rs2271001、rs111885243、rs2074233、rs622082、rs546382、rs185257411、rs145509540、rs144650014、rs17103265、rs11570779、rs17793018、rs76846944、rs698028、rs4923849、rs12904657、rs72765429、rs111980103、rs61737565、rs4788099、rs7198606、rs62037369、rs62037371、rs10499、rs13337155、rs61742982、rs9303742、rs17223038、rs199667693、rs148965154、rs706764、rs56408444、rs117753855、rs78472358、rs6037509、rs150212573、rs147911723、rs470101;4)rs3795262、rs12409277、rs61735125、rs61746709、rs191051279、rs151112364、rs2291804、rs12408385、rs2275365、rs2275360、rs146696696、rs11542470、rs12386、rs74622002、rs368345074、rs142732858、rs80002732、rs374309842、rs144649977、rs78780269、rs2275863、rs77901289、rs191506876、rs117369152、rs147707514、rs6715296、rs3087649、rs7584256、rs10177030、rs11694145、rs4149520、rs143100530、rs1434087、rs77497147、rs2004888、rs11568351、rs141302000、rs3748962、rs11574750、rs16858808、rs16858811、rs141559295、rs3769838、rs6734083、rs28900693、rs4663795、rs34401965、rs76999397、rs11919775、rs1869852、rs1869851、rs1077827、rs80341144、rs3213930、rs2029618、rs75318799、rs11719458、rs33988592、rs79845192、rs41298993、rs2124541、rs66748594、rs28372853、rs572169、rs2246901、rs73189480、rs3733217、rs34611001、rs61746000、rs117486807、rs147434354、rs35762546、rs3749584、rs2271036、rs2271037、rs10517195、rs41498446、rs3733324、rs2271924、rs1801612、rs2280099、rs8582、rs13147012、rs79482316、rs3827497、rs26173、rs26098、rs26107、rs26086、rs1051489、rs2270915、rs3813474、rs1353252、rs1353251、rs1494561、rs1353250、rs5867289、rs1494558、rs1494555、rs987106、rs2233216、rs2233213、rs3217552、rs16874505、rs3749684、rs3729668、rs28388868、rs144533176、rs42688、rs32210、rs13180243、rs154483、rs367805、rs2631368、rs117231680、rs10053292、rs7701410、
rs11249552、rs142883877、rs150856424、rs3734391、rs9370867、rs77229316、rs17194565、rs117487649、rs1264319、rs35756329、rs17201248、rs190135313、rs7764126、rs11755393、rs13205210、rs3734264、rs1051115、rs74609186、rs6928630、rs143580489、rs1204114、rs10484690、rs118151455、rs143904280、rs9459355、rs9459356、rs113806172、rs10227750、rs200111157、rs539973087、rs182692351、rs13306387、rs79809732、rs113281844、rs201920957、rs236652、rs236655、rs236666、rs79960636、rs112596877、rs117509972、rs772373052、rs801841、rs1062394、rs200333762、rs4301376、rs775410128、rs3987896、rs146160185、rs17171113、rs2788473、rs189212243、rs74699763、rs2584、rs41488144、rs13306550、rs77061383、rs145349678、rs371193886、rs8178175、rs4925828、rs7023474、rs3802392、rs4879781、rs35066989、rs112858544、rs1164863576、rs16909677、rs117738198、rs117569740、rs147367410、rs61748723、rs16916100、rs2297530、rs77309503、rs77564189...

【专利技术属性】
技术研发人员:徐良德王宏
申请(专利权)人:温州眼视光国际创新中心
类型:发明
国别省市:

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