治疗增生性瘢痕、疤痕的小干扰核苷酸双链及其应用制造技术

本发明专利技术属于生物医疗技术领域，本发明专利技术公开了一种FKBP10在作为增生性瘢痕的治疗靶点方面的应用。本发明专利技术还公开了一种治疗增生性瘢痕、疤痕的小干扰核苷酸双链，小干扰核苷酸双链由FKBP10作为靶点设计得到。本发明专利技术另外还公开一种用于治疗增生性瘢痕的药物，至少包括以FKBP10为靶点设计的小干扰核苷酸双链。本发明专利技术公开一种治疗增生性瘢痕的方法，包括以下过程：以FKBP10为靶点，设计小干扰核苷酸双链；从中选择最有效的siRNA；将这些选定的siRNA进行修饰或与载体制备成纳米颗粒制剂；采用皮下或皮内注射治疗增生性瘢痕。本发明专利技术以FKBP10为靶点所设计的siRNA经过修饰或与载体形成纳米颗粒将成为治疗增生性瘢痕、疤痕的特效药，具有广阔的应用市场。广阔的应用市场。广阔的应用市场。

【技术实现步骤摘要】
治疗增生性瘢痕、疤痕的小干扰核苷酸双链及其应用


[0001]本专利技术属于生物医疗领域，尤其涉及治疗增生性瘢痕、疤痕的小干扰核苷酸双链及其应用，具体涉及一种FKBP10在作为增生性瘢痕的治疗靶点方面的应用，一种治疗增生性瘢痕、疤痕的小干扰核苷酸双链，一种用于治疗增生性瘢痕的药物，一种治疗增生性瘢痕的方法，一种用于增生性瘢痕诊断或治疗的生物标志物。

技术介绍

[0002]增生性瘢痕的病理基础是以成纤维细胞为主的细胞成分的过度增殖和以胶原为主的细胞外基质的过度沉积，这种增生性瘢痕的特点是损伤后炎症反应延长，导致局部成纤维细胞的血管化、细胞增生和过量胶原沉积。致病因素主要包括：代谢异常、细胞因子、低氧和自由基、基因水平变化。
[0003]目前国内外治疗瘢痕多采用局部药物封闭、皮肤移植、手术切除植皮、晶体磨疤术、气囊扩张术、抗体注射、放射治疗、压迫疗法、激素疗法、硅酮类等疗法；但是，现有治疗增生性瘢痕的技术在临床上都不是很成熟,疗效有待观察；而且，有的治疗方法所需治疗时间长，治疗痛苦大，而且容易反复，出现不良后果等，治疗效果都不尽如人意。...

【技术保护点】

【技术特征摘要】
1.一种FKBP10在作为增生性瘢痕的治疗靶点方面的应用。2.一种治疗增生性瘢痕、疤痕的小干扰核苷酸双链，其特征在于，所述小干扰核苷酸双链由FKBP10作为靶点设计得到。3.根据权利要求2所述的一种治疗增生性瘢痕、疤痕的小干扰核苷酸双链，其特征在于，所述小干扰核苷酸双链的序列为下列序列中的一条或一条以上：SiRNA
‑
FKBP10
‑
1：正义链：5
‘‑
AGCUCAAGCUGAAGUCAGA
‑3’
(SEQ ID NO.1)，反义链：5
‘‑
UCUGACUUCAGCUUGAGCU
‑3’
(SEQ ID NO.2)；SiRNA
‑
FKBP10
‑
2：正义链：5
‘‑
GAAGAUGUGGUCAUCGAGA
‑3’
(SEQ ID NO.3)，反义链：5
‘‑
UCUCGAUGACCACAUCUUC
‑3’
(SEQ ID NO.4)；SiRNA
‑
FKBP10
‑
3：正义链：5
‘‑
AGCUGAAGUCAGAUGAGGAC
‑3’
(SEQ ID NO.5)，反义链：5
‘‑
UCCUCAUCUGACUUCAGCUUG
‑3’
(SEQ ID NO.6)；SiRNA
‑
FKBP10
‑
4：正义链：5
‘‑
GAAGAUGUGGUCAUCGAGAG
‑3’
(SEQ ID NO.7)，反义链：5
‘‑
UCUCGAUGACCACAUCUUCCA
‑3’
(SEQ ID NO.8)；SiRNA
‑
FKBP10
‑
5：正义链：5
‘‑
UGGAAGAUGUGGUCAUCGA
‑3’
(SEQ ID NO.9)，反义链：5
‘‑
UCGAUGACCACAUCUUCCA
‑3’
(SEQ ID NO.10)；SiRNA
‑
FKBP10
‑
6：正义链：5
‘‑
GCUCAAGCUGAAGUCAGAU
‑3’
(SEQ ID NO.11)，反义链：5
‘‑
AUCUGACUUCAGCUUGAGC
‑3’
(SEQ ID NO.12)；SiRNA
‑
FKBP10
‑
7：正义链：5
‘‑
UGGGCAUGUGUGUCAACGAGC
‑3’
(SEQ ID NO.13)，反义链：5
‘‑
UCGUUGACACACAUGCCCAUG(SEQ ID NO.14)；SiRNA
‑
FKBP10
‑
8：正义链：5
‘‑
AGCUGAAGUCAGAUGAGGA
‑3’
(SEQ ID NO.15)，反义链：5
‘‑
UCCUCAUCUGACUUCAGCU
‑3’
(SEQ ID NO.16)；SiRNA
‑
FKBP10
‑
9：正义链：5
‘‑
GGGCAUGUGUGUCAACGAGCG
‑3’
(SEQ ID NO.17)，反义链：5
‘‑
CUCGUUGACACACAUGCCCAU
‑3’
(SEQ ID NO.18)；SiRNA
‑
FKBP10
‑
10：正义链：5
‘‑
UCAUGGGCAUGUGUGUCAA
‑3’
(SEQ ID NO.19)，反义链：5
‘‑
UUGACACACAUGCCCAUGA
‑3’
(SEQ ID NO.20)；SiRNA
‑
FKBP10
‑
11：正义链：5
‘‑
GCUCAAGCUGAAGUCAGAUGA
‑3’
(SEQ ID NO.21)，反义链：5
‘‑
AUCUGACUUCAGCUUGAGCUC
‑3’
(SEQ ID NO.22)；SiRNA
‑
FKBP10
‑
12：正义链：5
‘‑
CAGGCUACCUGUUUGUGUGG
‑3’
(SEQ ID NO.23)，反义链：5
‘‑
CACACAAACAGGUAGCCUGUG
‑3’
(SEQ ID NO.24)；SiRNA
‑
FKBP10
‑
13：正义链：5
‘‑
GGGCAUGUGUGUCAACGAG
‑3’
(SEQ ID NO.25)，反义链：5
‘‑
CUCGUUGACACACAUGCCC
‑3’
(SEQ ID NO.26)；SiRNA
‑
FKBP10
‑
14：正义链：5
‘‑
CCUUCAUCAAGGCUCAAGU
‑3’
(SEQ ID NO.27)，反义链：5
‘‑
ACUUGAGCCUUGAUGAAGG
‑3’
(SEQ ID NO.28)；SiRNA
‑
FKBP10
‑
15：正义链：5
‘‑
GCCUGCAGGGCAUGUGUGU
‑3’
(SEQ ID NO.29)，反义链：5
‘‑
ACACACAUGCCCUGCAGGC
‑3’
(SEQ ID NO.30)；SiRNA
‑
FKBP10
‑
16：正义链：5
‘‑
GGGCCUGCAGGGCAUGUGU
‑3’
(SEQ ID NO.31)，反义链：5
‘‑
ACACAUGCCCUGCAGGCCC
‑3’
(SEQ ID NO.32)；SiRNA
‑
FKBP10
‑
17：正义链：5
‘‑
CUUCAUCAAGGCUCAAGUG
‑3’
(SEQ ID NO.33)，反义链：5
‘‑
CACUUGAGCCUUGAUGAAG
‑3’
(SEQ ID NO.34)；
SiRNA
‑
FKBP10
‑
18：正义链：5
‘‑
UUCAUCAAGGCUCAAGUGA
‑3’
(SEQ ID NO.35)，反义链：5
‘‑
UCACUUGAGCCUUGAUGAAGG
‑3’
(SEQ ID NO.36)；SiRNA
‑
FKBP10
‑
19：正义链：5
‘‑
CAAAGGACGCCUCAUGCCU
‑3’
(SEQ ID NO.37)，反义链：5
‘‑
AGGCAUGAGGCGUCCUUUG
‑3’
(SEQ ID NO.38)；SiRNA
‑
FKBP10
‑
20：正义链：5
‘‑
UUCAUCAAGGCUCAAGUGA
‑3’
(SEQ ID NO.39)，反义链：5
‘‑
UCACUUGAGCCUUGAUGAA
‑3’
(SEQ ID NO.40)；SiRNA
‑
FKBP10
‑
21：正义链：5
‘‑
CCCGCAACCACACCUACAAUA
‑3’
(SEQ ID NO.41)，反义链：5
‘‑
UUGUAGGUGUGGUUGCGGGAG
‑3’
(SEQ ID NO.42)；SiRNA
‑
FKBP10
‑
22：正义链：5
‘‑
CGCAACCACACCUACAAUACC
‑3’
(SEQ ID NO.43)，反义链：5
‘‑
UAUUGUAGGUGUGGUUGCGGG
‑3’
(SEQ ID NO.44)；SiRNA
‑
FKBP10
‑
23：正义链：5
‘‑
GCAACCACACCUACAAUACCU
‑3’
(SEQ ID NO.45)，反义链：5
‘‑
AGGUAUUGUAGGUGUGGUUGC
‑3’
(SEQ ID NO.46)；SiRNA
‑
FKBP10
‑
24：正义链：5
‘‑
GAAGAUGUGGUCAUCGAGAGG
‑3’
(SEQ ID NO.47)，反义链：5
‘‑
UCUCGAUGACCACAUCUUCCA
‑3’
(SEQ ID NO.48)；SiRNA
‑
FKBP10
‑
25：正义链：5
‘‑
GGAUGUGUGGAACAAGGAAGA
‑3’
(SEQ ID NO.49)，反义链：5
‘‑
UUCCUUGUUCCACACAUCCAG
‑3’
(SEQ ID NO.50)；SiRNA
‑
FKBP10
‑
26：正义链：5
‘‑
GUGUGGAACAAGGAAGACACC
‑3’
(SEQ ID NO.51)，反义链：5
‘‑
UGUCUUCCUUGUUCCACACAU
‑3’
(SEQ ID NO.52)；SiRNA
‑
FKBP10
‑
27：正义链：5
‘‑
AGCUGAAGUCAGAUGAGGACG
‑3’
(SEQ ID NO.53)，反义链：5
‘‑
UCCUCAUCUGACUUCAGCUUG
‑3’
(SEQ ID NO.54)；SiRNA
‑
FKBP10
‑
28：正义链：5
‘‑
ACUUUGUCCGCUACCACUACA
‑3’
(SEQ ID NO.55)，反义链：5
‘‑
UAGUGGUAGCGGACAAAGUCG
‑3’
(SEQ ID NO.56)；SiRNA
‑
FKBP10
‑
29：正义链：5
‘‑
GGCGAGAAAGGCUAUGGGACA
‑3’
(SEQ ID NO.57)，反义链：5
‘‑
UCCCAUAGCCUUUCUCGCCAU
‑3’
(SEQ ID NO.58)；SiRNA
‑
FKBP10
‑
30：正义链：5
‘‑
GAGGAGUUCUCCACCUUCAUC
‑3’
(SEQ ID NO.59)，反义链：5
‘‑
UGAAGGUGGAGAACUCCUCCG
‑3’
(SEQ ID NO.60)；SiRNA
‑
FKBP10
‑
31：正义链：5
‘‑
GAGUUCUCCACCUUCAUCAAG
‑3’
(SEQ ID NO.61)，反义链：5
‘‑
UGAUGAAGGUGGAGAACUCCU
‑3’
(SEQ ID NO.62)；SiRNA
‑
FKBP10
‑
32：正义链：5
‘‑
AGUUCUCCACCUUCAUCAAGG
‑3’
(SEQ ID NO.63)，反义链：5
‘‑
UUGAUGAAGGUGGAGAACUCC
‑3’
(SEQ ID NO.64)；SiRNA
‑
FKBP10
‑
33：正义链：5
‘‑
CCAUAGGAGACAUGUUCCAGA
‑3’
(SEQ ID NO.65)，反义链：5
‘‑
UGGAACAUGUCUCCUAUGGUU
‑3’
(SEQ ID NO.66)；SiRNA
‑
FKBP10
‑
34：正义链：5
‘‑
UAGGAGACAUGUUCCAGAACC
‑3’
(SEQ ID NO.67)，反义链：5
‘‑
UUCUGGAACAUGUCUCCUAUG
‑3’
(SEQ ID NO.68)；SiRNA
‑
FKBP10
‑
35：正义链：5
‘‑
AGCUCAAGCUGAAGUCAGAUG
‑3’
(SEQ ID NO.69)，反义链：5
‘‑
UCUGACUUCAGCUUGAGCUCG
‑3’
(SEQ ID NO.70)；SiRNA
‑
FKBP10
‑
36：正义链：5
‘‑
UGCUGGAUGUGUGGAACAAGG
‑3’
(SEQ ID NO.71)，反义链：5
‘‑
UUGUUCCACACAUCCAGCAGA
‑3’
(SEQ ID NO.72)；SiRNA
‑
FKBP10
‑
37：正义链：5
‘‑
CACACCUACAAUACCUAUAUC
‑3’
(SEQ ID NO.73)，
反义链：5
‘‑
UAUAGGUAUUGUAGGUGUGGU
‑3’
(SEQ ID NO.74)；SiRNA
‑
FKBP10
‑
38：正义链：5
‘‑
CGGAGGAGUUCUCCACCUUCA
‑3’
(SEQ ID NO.75)，反义链：5
‘‑
AAGGUGGAGAACUCCUCCGGA
‑3’
(SEQ ID NO.76)；SiRNA
‑
FKBP10
‑
39：正义链：5
‘‑
GGCAAGAAGUUUGAUUCAAGC
‑3’
(SEQ ID NO.77)，反义链：5
‘‑
UUGAAUCAAACUUCUUGCCAU
‑3’
(SEQ ID NO.78)；SiRNA
‑
FKBP10
‑
40：正义链：5
‘‑
GAAGUUUGAUUCAAGCUAUGA
‑3’
(SEQ ID NO.79)，反义链：5
‘‑
AUAGCUUGAAUCAAACUUCUU
‑3’
(SEQ ID NO.80)；SiRNA
‑
FKBP10
‑
41：正义链：5
‘‑
GUUUGAUUCAAGCUAUGAUCG
‑3’
(SEQ ID NO.81)，反义链：5
‘‑
AUCAUAGCUUGAAUCAAACUU
‑3’
(SEQ ID NO.82)；SiRNA
‑
FKBP10
‑
42：正义链：5
‘‑
GAUUCAAGCUAUGAUCGCAAC
‑3’
(SEQ ID NO.83)，反义链：5
‘‑
UGCGAUCAUAGCUUGAAUCAA
‑3’
(SEQ ID NO.84)；SiRNA
‑
FKBP10
‑
43：正义链：5
‘‑
GGAGAGAGAAGGAAGAUUAUC
‑3’
(SEQ ID NO.85)，反义链：5
‘‑
UAAUCUUCCUUCUCUCUCCAG
‑3’
(SEQ ID NO.86)；SiRNA
‑
FKBP10
‑
44：正义链：5
‘‑
GAGAGAAGGAAGAUUAUCAUC
‑3’
(SEQ ID NO.87)，反义链：5
‘‑
UGAUAAUCUUCCUUCUCUCUC
‑3’
(SEQ ID NO.88)；SiRNA
‑
FKBP10
‑
45：正义链：5
‘‑
CUGCCGUGCUAAUCUUCAACG
‑3’
(SEQ ID NO.89)，反义链：5
‘‑
UUGAAGAUUAGCACGGCAGAG
‑3’
(SEQ ID NO.90)；SiRNA
‑
FKBP10
‑
46：正义链：5
‘‑
CGAUACCAUUACAACUGUUCU
‑3’
(SEQ ID NO.91)，反义链：5
‘‑
AACAGUUGUAAUGGUAUCGAA
‑3’
(SEQ ID NO.92)；SiRNA
‑
FKBP10
‑
47：正义链：5
‘‑
GAGACAUGUUCCAGAACCAGG
‑3’
(SEQ ID NO.93)，反义链：5
‘‑
UGGUUCUGGAACAUGUCUCCU
‑3’
(SEQ ID NO.94)；SiRNA
‑
FKBP10
‑
48：正义链：5
‘‑
CUACCGUGUUUCUCUUCCAUC
‑3’
(SEQ ID NO.95)，反义链：5
‘‑
UGGAAGAGAAACACGGUAGAG
‑3’
(SEQ ID NO.96)；SiRNA
‑
FKBP10
‑
49：正义链：5
‘‑
CAGCUGAGCUUGUUAUCCAUC
‑3’
(SEQ ID NO.97)，反义链：5
‘‑
UGGAUAACAAGCUCAGCUGUG
‑3’
(SEQ ID NO.98)；SiRNA
‑
FKBP10
‑
50：正义链：5
‘‑
CUUUCUCUUUCUUUGUACUUC
‑3’
(SEQ ID NO.99)，反义链：5
‘‑
AGUACAAAGAAAGAGAAAGUU
‑3’
(SEQ ID NO.100)；SiRNA
‑
FKBP10
‑
51：正义链：5
‘‑
CUUUCUUUGUACUUCUUGUCA
‑3’
(SEQ ID NO.101)，反义链：5
‘‑
ACAAGAAGUACAAAGAAAGAG
‑3’
(SEQ ID NO.102)；SiRNA
‑
FKBP10
‑
52：正义链：5
‘‑
GAACCAUAGAAGAGAGGAAGA
‑3’
(SEQ ID NO.103)，反义链：5
‘‑
UUCCUCUCUUCUAUGGUUCCU
‑3’
(SEQ ID NO.104)；SiRNA
‑
FKBP10
‑
53：正义链：5
‘‑
GAGAGAGAAGGAAGAUUAUCA
‑3’
(SEQ ID NO.105)，反义链：5
‘‑
UGAUAAUCUUCCUUCUCUCUC
‑3’
(SEQ ID NO.106)；SiRNA
‑
FKBP10
‑
54：正义链：5
‘‑
GAAAGGCUAUGGGACAGUGAU
‑3’
(SEQ ID NO.107)，反义链：5
‘‑
AUCACUGUCCCAUAGCCUUUC
‑3’
(SEQ ID NO.108)；SiRNA
‑
FKBP10
‑
55：正义链：5
‘‑
GGACUUCAUGCGCUACCACUA
‑3’
(SEQ ID NO.109)，反义链：5
‘‑
UAGUGGUAGCGCAUGAAGUCC
‑3’
(SEQ ID NO.110)；SiRNA
‑
FKBP10
‑
56：正义链：5
‘‑
GCACUUAUGACACCUACGUCG
‑3’
(SEQ ID NO.111)，反义链：5
‘‑
ACGUAGGUGUCAUAAGUGCCG
‑3’
(SEQ ID NO.112)；
SiRNA
‑
FKBP10
‑
57：正义链：5
‘‑
CCGUGCUAAUCUUCAACGUCC
‑3’
(SEQ ID NO.113)，反义链：5
‘‑
ACGUUGAAGAUUAGCACGGCA
‑3’
(SEQ ID NO.114)；SiRNA
‑
FKBP10
‑
58：正义链：5
‘‑
CCCUGGAAGAUGUGGUCAUCG
‑3’
(SEQ ID NO.115)，反义链：5
‘‑
AUGACCACAUCUUCCAGGGGG
‑3’
(SEQ ID NO.116)；SiRNA
‑
FKBP10
‑
59：正义链：5
‘‑
CCUGCUGCAGUUGCUGCUACU
‑3’
(SEQ ID NO.117)，反义链：5
‘‑
UAGCAGCAACUGCAGCAGGGG
‑3’
(SEQ ID NO.118)；SiRNA
‑
FKBP10
‑
60：正义链：5
‘‑
CUCUUUCUUUGUACUUCUUGU
‑3’
(SEQ ID NO.119)，反义链：5
‘‑
AAGAAGUACAAAGAAAGAGAA
‑3’
(SEQ ID NO.120)；SiRNA
‑
FKBP10
‑
61：正义链：5
‘‑
GCUAUGAAAUCUUGGAUUUGG
‑3’
(SEQ ID NO.121)，反义链：5
‘‑
AAAUCCAAGAUUUCAUAGCCC
‑3’
(SEQ ID NO.122)；SiRNA
‑
FKBP10
‑
62：正义链：5
‘‑
UGGAAGAUGUGGUCAUCGAGA
‑3’
(SEQ ID NO.123)，反义链：5
‘‑
UCGAUGACCACAUCUUCCAGG
‑3’
(SEQ ID NO.124)；SiRNA
‑
FKBP10
‑
63：正义链：5
‘‑
CUACAACGGCACUUUUGAAGA
‑3’
(SEQ ID NO.125)，反义链：5
‘‑
UUCAAAAGUGCCGUUGUAGUG
‑3’
(SEQ ID NO.126)；SiRNA
‑
FKBP10
‑
64：正义链：5
‘‑
AGAAGUUUGAUUCAAGCUAUG
‑3’
(SEQ ID NO.127)，反义链：5
‘‑
UAGCUUGAAUCAAACUUCUUG
‑3’
(SEQ ID NO.128)；SiRNA
‑
FKBP10
‑
65：正义链：5
‘‑
CCUCUACUUCGAUGUGGUUCU
‑3’
(SEQ ID NO.129)，反义链：5
‘‑
AACCACAUCGAAGUAGAGGGU
‑3’
(SEQ ID NO.130)；SiRNA
‑
FKBP10
‑
66：正义链：5
‘‑
CGAUGUGGUUCUGCUGGAUGU
‑3’
(SEQ ID NO.131)，反义链：5
‘‑
AUCCAGCAGAACCACAUCGAA
‑3’
(SEQ ID NO.132)；SiRNA
‑
FKBP10
‑
67：正义链：5
‘‑
GCAUGGUCCAGGACGGCGACU
‑3’
(SEQ ID NO.133)，反义链：5
‘‑
UCGCCGUCCUGGACCAUGCGG
‑3’
(SEQ ID NO.134)；SiRNA
‑
FKBP10
‑
68：正义链：5
‘‑
GGUCCAGGACGGCGACUUUGU
‑3’
(SEQ ID NO.135)，反义链：5
‘‑
AAAGUCGCCGUCCUGGACCAU
‑3’
(SEQ ID NO.136)；SiRNA
‑
FKBP10
‑
69：正义链：5
‘‑
CCUCCUUCGACACCAGCUACA
‑3’
(SEQ ID NO.137)，反义链：5
‘‑
UAGCUGGUGUCGAAGGAGGUG
‑3’
(SEQ ID NO.138)；SiRNA
‑
FKBP10
‑
70：正义链：5
‘‑
GAGAGAGAAGGAAGAUUAUCA
‑3’
(SEQ ID NO.139)，反义链：5
‘‑
AUAAUCUUCCUUCUCUCUCCA
‑3’
(SEQ ID NO.140)；SiRNA
‑
FKBP10
‑
71：正义链：5
‘‑
GAAGGACGCUGUCCAGCUAGA
‑3’
(SEQ ID NO.141)，反义链：5
‘‑
UAGCUGGACAGCGUCCUUCGG
‑3’
(SEQ ID NO.142)；SiRNA
‑
FKBP10
‑
72：正义链：5
‘‑
CCCUCUUCGAUUCCAGCUACU
‑3’
(SEQ ID NO.143)，反义链：5
‘‑
UAGCUGGAAUCGAAGAGGGUG
‑3’
(SEQ ID NO.144)；SiRNA
‑
FKBP10
‑
73：正义链：5
‘‑
GGAGAAUGGAACUGGAGACAA
‑3’
(SEQ ID NO.145)，反义链：5
‘‑
UUGUCUCCAGUUCCAUUCUCC
‑3’
(SEQ ID NO.146)；SiRNA
‑
FKBP10
‑
74：正义链：5
‘‑
GAAUGGAACUGGAGACAAGAU
‑3’
(SEQ ID NO.147)，反义链：5
‘‑
AUCUUGUCUCCAGUUCCAUUC
‑3’
(SEQ ID NO.148)；SiRNA
‑
FKBP10
‑
75：正义链：5
‘‑
AUGUCAUUGACUUCCACAACC
‑3’
(SEQ ID NO.149)，反义链：5
‘‑
UUGUGGAAGUCAAUGACAUGG
‑3’
(SEQ ID NO.150)；SiRNA
‑
FKBP10
‑
76：正义链：5
‘‑
CCUGCAAUGAGACCACCAAGC
‑3’
(SEQ ID NO.151)，
反义链：5
‘‑
UUGGUGGUCUCAUUGCAGGUC
‑3’
(SEQ ID NO.152)；SiRNA
‑
FKBP10
‑
77：正义链：5
‘‑
GGGACUUUGUUCGAUACCAUU
‑3’
(SEQ ID NO.153)，反义链：5
‘‑
UGGUAUCGAACAAAGUCCCCA
‑3’
(SEQ ID NO.154)；SiRNA
‑
FKBP10
‑
78：正义链：5
‘‑
GACUUUGUUCGAUACCAUUAC
‑3’
(SEQ ID NO.155)，反义链：5
‘‑
AAUGGUAUCGAACAAAGUCCC
‑3’
(SEQ ID NO.156)；SiRNA
‑
FKBP10
‑
79：正义链：5
‘‑
GCAGUGCUGUGCUGCUGUUUG
‑3’
(SEQ ID NO.157)，反义链：5
‘‑
AACAGCAGCACAGCACUGCCU
‑3’
(SEQ ID NO.158)；SiRNA
‑
FKBP10
‑
80：正义链：5
‘‑
GUGCUGUGCUGCUGUUUGAGG
‑3’
(SEQ ID NO.159)，反义链：5
‘‑
UCAAACAGCAGCACAGCACUG
‑3’
(SEQ ID NO.160)；SiRNA
‑
FKBP10
‑
81：正义链：5
‘‑
CCACCUUCAUCAAGGCUCAAG
‑3’
(SEQ ID NO.161)，反义链：5
‘‑
UGAGCCUUGAUGAAGGUGGAG
‑3’
(SEQ ID NO.162)；SiRNA
‑
FKBP10
‑
82：正义链：5
‘‑
CACCUUCAUCAAGGCUCAAGU
‑3’
(SEQ ID NO.163)，反义链：5
‘‑
UUGAGCCUUGA...

【专利技术属性】
技术研发人员：孙婷婷，陈璞，
申请(专利权)人：纳肽得有限公司，
类型：发明
国别省市：