The invention discloses a pill for alleviating senile dementia and a preparation method. The effective ingredients of the pill are as follows by weight: cooked ground 40 820 50, yam 28 820 32, cornwood 28 820 32, corncorncornwood 28 820 32, CiCistanche 28 820 32, prepared acaconiseed 9 8209 11, fucococos 18 820, porporporia cocos 18 22, acacacorororus 11 11 13, acacacacaricuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscuscus9;11 copies, wheat There were 18 22 portions of Mendong, 9 11 portions of Cinnamon, 18 22 portions of Dendrobium, 5 7 portions of Chuanbei, 5 7 portions of Astragalus and 11 13 portions of Codonopsis pilosula. The preparation method of the pill includes the following steps: decocting and extracting the active ingredients together to make a thick paste; adding sodium carboxymethyl starch, microcrystalline cellulose and lactose to mix and make soft pills; adding soft pills into the extrusion spheronizing granulator, extrusion spheronization to make pills; drying the prepared pills to obtain products. The pill of the invention has low toxicity and side effects, and has remarkable effect on senile dementia. The preparation process of the pill of the invention is simple and suitable for industrial production.
【技术实现步骤摘要】
一种缓解老年痴呆的丸剂及制备方法
本专利技术属于中药领域,具体涉及一种缓解老年痴呆的丸剂及其制备方法。
技术介绍
老年痴呆是指由于老年脑功能障碍而产生的获得性智能损害综合征,临床上以记忆、认知障碍,智能减退,影响工作和社交活动为特点,相当于中药学“健忘”、“痴呆”、“呆病”等疾病范围。西医认为,AD的发病机理与基因遗传、氧自由基、铝蓄积、细胞凋亡、钙离子等多种因素有关,其特征性病理改变为老年斑(SP)、神经元纤维缠结(NFT)及神经元丢失。目前,西医对老年痴呆的病因主要几种在以下几种假说:胆碱能学说、炎症学说、自由基学说、铝中毒学说、基因变异学说、Aβ级联假说。对老年痴呆的治疗主要采用胆碱酯酶抑制剂,如盐酸多奈哌齐(Donepezil)、加兰他敏(Galantamine)和艾斯能(Rivastigmine)和兴奋性氨基酸受体拮抗剂,如盐酸美金刚(Memantine),它们能短期改善痴呆患者的症状但不能延缓疾病发展。中医认为,人至老年或久病,五脏之气渐衰,气血精液化生不足,精亏于下,不能上充于脑,髓海空衰,元神失养,神明失聪,是痴呆发生的主要病理机制,肾中精气衰减是老年痴呆发病的根本,故治疗老年痴呆,应该以补肾填精为基本治疗方法,如陈京萍等用补肾益智方对老年痴呆模型大鼠中枢递质及受体的试验印证“肾生骨髓”等理论,王平等用补肾中药(黄精、枸杞子、石菖蒲等)等探讨了老年痴呆的形态学机制,认为补肾中药对海马超微结构有明显改善,提供了海马神经元病变符合中医“髓海不足”,“脑髓衰减”的改变的客观依据。岳启安等以呆聪液(人参、生地、知母、黄芪等)对老龄大鼠痴呆模型脑M受 ...
【技术保护点】
1.一种缓解老年痴呆的丸剂,其特征在于,其药效成分按重量份计:熟地40‑50份,山药28‑32份,山茱萸28‑32份,肉苁蓉28‑32份,制附子9‑11份,茯苓18‑22份,石菖蒲11‑13份,远志9‑11份,化橘红13‑16份,巴戟天18‑22份,五味子9‑11份,麦门冬18‑22份,肉桂9‑11份,石斛18‑22份,川贝5‑7份,黄芪5‑7份,党参11‑13份。
【技术特征摘要】
1.一种缓解老年痴呆的丸剂,其特征在于,其药效成分按重量份计:熟地40-50份,山药28-32份,山茱萸28-32份,肉苁蓉28-32份,制附子9-11份,茯苓18-22份,石菖蒲11-13份,远志9-11份,化橘红13-16份,巴戟天18-22份,五味子9-11份,麦门冬18-22份,肉桂9-11份,石斛18-22份,川贝5-7份,黄芪5-7份,党参11-13份。2.如权利要求1所述的缓解老年痴呆的丸剂,其特征在于,其药效成分按重量份计:熟地45份,山药30份,山茱萸30份,肉苁蓉30份,制附子10份,茯苓20份,石菖蒲12份,远志10份,化橘红15份,巴戟天20份,五味子10份,麦门冬20份,肉桂10份,石斛20份,川贝6份,黄芪6份,党参12份。3.权利要求1至2中任一项所述的缓解老年痴呆的丸剂的制备方法,其特征在于,包括如下步骤:(1)将熟地,山药,山茱萸,肉苁蓉,制附子,茯苓,石菖蒲,远志,化橘红,巴戟天,五味子,麦门冬,肉桂,石斛,川贝,黄芪,党参按照上述重量配比加...
【专利技术属性】
技术研发人员:石玥,
申请(专利权)人:梅州华普医院有限公司,
类型:发明
国别省市:广东,44
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