The invention relates to a two hydrogen myricetin agent based on polyoxyethylene dehydrated sorbitol monoglycate and chitosan as carrier and a preparation method. The preparation is composed of two megacenetin, polyoxyethylene dehydrated sorbitol mono oleate, chitosan, isopropyl myrisate and water, through phase mapping and small amount of water. The angle X ray diffraction is used to characterize the sample type. The content of chitosan, the influence of oil content, the influence of water content and the pH value of the system affect the release of two hydrogen myricetin. The chitosan is dissolved in the system and forms a stable aggregate. The coordination and coordination of the components of the prepared agents can control the release of the two hydrogen myricetin drugs. The release curves were fitted by different release kinetics models. It was found that the release process was more consistent with the first order kinetics, indicating that the release of two HP in the sample was caused by the concentration diffusion.
【技术实现步骤摘要】
一种基于Tween80和壳聚糖的聚集体为载体的二氢杨梅素药剂及制备方法
本专利技术属于药剂制备
,具体涉及一种基于Tween80和壳聚糖的聚集体为载体的二氢杨梅素药剂及制备方法。
技术介绍
二氢杨梅素(DMY)是一种从植物中提取的天然黄酮的化合物,因有众多的生理活性而被广泛关注,如保护肝脏,调节血脂,抗菌,抗氧化等。然而,其在水中的溶解性较差(0.2mg/mL,25℃),导致其生物利用度低,大大限制了实际运用。近年来,为了改善DMY的上述问题,近年来通过药物载体例如微乳液,脂质体,胶束等对DMY进行包载,实现对药物的增溶,以提高DMY的溶解度成为了研究的热点。表面活性剂是一类同时具有亲水头基和疏水尾巴的两亲性的有机化合物,分子的疏水尾巴相互缔合形成胶束,当表面活性剂的浓度超过这一值时,会在水溶液中自发组成胶束聚集体。当内部胶束聚集到一定的临界水平,就会存在一个溶致液晶相。在结构上为短程无序,长程有序的有序聚集体。主要分为六角相,层状相,立方相液晶,其中六角相为棒状胶束在二维上有序排列而形成的,在其疏水的内核中可以增溶油溶性物质,在其亲水区域可以增溶水溶性化合 ...
【技术保护点】
一种基于Tween 80和壳聚糖的聚集体为载体的二氢杨梅素药剂,包括二氢杨梅素、Tween 80、壳聚糖、肉豆蔻酸异丙酯和水组成;Tween 80、壳聚糖、肉豆蔻酸异丙酯和水组成载体体系,载体的质量组成为Tween 80占34~44份,壳聚糖占0~8份,肉豆蔻酸异丙酯占2~11份,水占的45~53;其中壳聚糖的质量不为0。
【技术特征摘要】
1.一种基于Tween80和壳聚糖的聚集体为载体的二氢杨梅素药剂,包括二氢杨梅素、Tween80、壳聚糖、肉豆蔻酸异丙酯和水组成;Tween80、壳聚糖、肉豆蔻酸异丙酯和水组成载体体系,载体的质量组成为Tween80占34~44份,壳聚糖占0~8份,肉豆蔻酸异丙酯占2~11份,水占的45~53;其中壳聚糖的质量不为0。2.根据权利要求1所述的二氢杨梅素药剂,其特征在于:二氢杨梅素的浓度为1.5mg/g。3.根据权利要求1所述的二氢杨梅素药剂,其特征在于:所述表面活性剂与油相的比例为4:1。4.根据权利要求1所述的二氢杨梅素药剂,其特征在于:所述壳聚糖的溶解度为0.04g/g。5.根据权利要求1所述的二氢杨梅素药剂,其特征在于:药剂的pH值为7.4。6.一种二氢杨梅素药剂制备方法,其特征在于:具体步骤为:1)按照一定的质量比Tw...
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