The invention discloses a kind of liver lobule bioreactor, belonging to the field of biomedical equipment. A nano fibrous scaffold net is arranged in the shell of the liver fibrous vascular net, bile capillary network, liver bile duct, hepatic duct, common bile duct and hepatic collagen fibers distributed throughout the micro channel network around the nanofiber scaffold, and capillary bile and distribution of collagen fiber in hepatocyte micro channel; liver bile duct and the hepatic duct communicated through common bile duct; bile duct bile capillary capillary in the network with more than two cholangiole epithelial cells of liver cell entrance; collagen fiber micro channel with more than two liver cells into the mouth; the liver fibrous vascular network is provided with a liquid inlet and a liquid outlet; the exit capillary entrance, bile duct epithelial cells of liver cells an injection port, a liquid inlet, a liquid outlet and common bile duct through the shell. The invention truly simulates the structure of the hepatic lobule, plays the functions of metabolism, detoxication and excretion of the liver, and is not available for any biological reactor in the past.
【技术实现步骤摘要】
【技术保护点】
1.一种类肝小叶生物反应器,其特征是:包括封闭式外壳(14),在外壳(14)内设有纳米纤维支架网(15),肝内纤维血管网(9)、毛细胆管网(12)、上肝胆管(7)、下肝胆管(8)、胆总管(10)和肝细胞胶原纤维微管道(13)分布于整个纳米纤维支架网(15)中,且毛细胆管网(12)分布于肝细胞胶原纤维微管道(13)的周围;上肝胆管(7)和下肝胆管(8)通过胆总管(10)连通;毛细胆管网(12)中的毛细胆管设有两个以上毛细胆管上皮细胞入口;肝细胞胶原纤维微管道(13)设有两个以上肝细胞注入口;肝内纤维血管网(9)设有液体进口(1)和液体出口(6);所述毛细胆管上皮细胞入口、肝细胞注入口、液体进口(1)、液体出口(6)和胆总管(10)的下端出口穿过所述外壳(14)。
【技术特征摘要】
【专利技术属性】
技术研发人员:李兰娟,喻成波,章益民,潘小平,杜维波,曹红翠,吕国良,黄建荣,
申请(专利权)人:浙江大学,
类型:发明
国别省市:86
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