野菊花总黄酮在制备防治心肌肥大、心室重构药物中的应用制造技术

本发明专利技术属于医药技术领域，具体地说，涉及野菊花总黄酮在制备防治心肌肥大、心室重构药物中的应用。野菊花总黄酮能够降低小鼠心肌肥厚指数和心肌ＡｎｇＩＩ含量。野菊花总黄酮能够降低压力超负荷大鼠心肌肥厚指数、血压、神经内分泌因子、心肌Ｈｙｐ含量、缩小压力超负荷大鼠左室心肌细胞横截面积、减少心肌胶原沉积、调节心肌ＭＭＰ－２、ＭＭＰ－９蛋白和ｍＲＮＡ的异常表达。

Application of total flavonoids of Chrysanthemum indicum in preparation of medicament for preventing and treating myocardial hypertrophy and ventricular remodeling

The invention belongs to the technical field of medicine, in particular to the application of total flavonoids of Chrysanthemum indicum in preparing medicine for preventing and treating cardiac hypertrophy and ventricular remodeling. Total flavonoids of Chrysanthemum indicum can reduce the cardiac hypertrophy index and myocardial AngII content in mice. The abnormal expression of total flavonoids of chrysanthemum can reduce the pressure, myocardial hypertrophy index, blood pressure overload rat neuroendocrine factors and myocardial Hyp content and reduced left ventricular pressure overload rat cardiomyocyte cross-sectional area, reduce the myocardial collagen deposition, regulation of myocardial MMP - 2 and MMP - 9 protein and mRNA.

【技术实现步骤摘要】

【技术保护点】
野菊花总黄酮在制备防治心肌肥大、心室重构药物中的应用。

【技术特征摘要】

【专利技术属性】
技术研发人员：吴琦，陈长勋，顾伟梁，
申请(专利权)人：上海中医药大学，
类型：发明
国别省市：31[中国|上海]