The invention belongs to the field of gene function and application, and relates to an hrbp1 as a target for screening drugs for controlling tobacco mosaic virus and its application. The invention provides a target for screening drugs for preventing and controlling tobacco mosaic virus, and the target is tobacco cell wall receptor protein hrbp1. The invention also provides an application of tobacco cell wall receptor protein hrbp1 as a drug target in screening drugs for the prevention and control of tobacco mosaic virus. Aiming at the mechanism of TMV of tobacco mosaic virus in the process of virus transmission, hrbp1 is used as the target of potential antiviral agents for the first time in the present invention, and the interaction between existing dufulin and it is studied. Because the combined expression of hrbp1 in vitro exists in an aggregation state, and dufulin, an anti plant virus candidate drug, cannot destroy the aggregation state, dufulin can activate or maintain the aggregation state of hrbp1 The polymers of hrbp1 protein can be used as target proteins of TMV active compounds and candidate drugs.
【技术实现步骤摘要】
HrBP1作为筛选防治烟草花叶病毒的药物的靶标及其应用
本专利技术涉及一种HrBP1作为筛选防治烟草花叶病毒的药物的靶标及其应用，属于基因的功能与应用领域。
技术介绍
烟草花叶病毒tobaccomosaicvirus缩写TMV，为RNA病毒，是烟草花叶病等的病原体，是目前烟草生产上分布最广、发生最为普遍的一类病害，对烟草的危害极大。烟草花叶病毒侵染烟草植株后，会破坏植株的组织结构，对嫩叶的破坏力度最大，使嫩叶出现明脉症状，即叶片侧脉及支脉组织出现半透明的现象，烟草花叶病毒在烟草细胞中大量繁殖，病毒RNA会严重影响烟草细胞的正常分裂，导致烟草叶肉细胞畸形裂变，部分烟草叶片大量繁殖或者受抑制，出现叶片厚度不均匀的症状，叶片出现斑点，呈现出黄绿相间的不同区域，随着花叶病毒的进一步侵染，逐步导致叶片组织坏死，烟草叶片出现大面积的褐色坏死斑，叶片形状扭曲、皱缩，这种现象在老叶片上尤为明显，重病的叶片凸起形成泡状，边缘向内弯曲。早期发病的烟草植株，严重矮化，烟草植株不能正常生长，在成熟期不能正常的开花结果，抵抗能力很差，容易受到外界的干...
【技术保护点】
1.一种筛选防治烟草花叶病毒的药物的靶标，其特征在于，所述靶标是烟草细胞壁受体蛋白HrBP1。/n
【技术特征摘要】
1.一种筛选防治烟草花叶病毒的药物的靶标，其特征在于，所述靶标是烟草细胞壁受体蛋白HrBP1。
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