The present invention discloses a preparation method of selenium sulfide compounds. By the action of trifluoromethanesulfonic acid and diethyl azodicarbonate with catalytic amount, the method can effectively oxidize and break the S_S (Se_Se) bond to produce sulfur or selenium positive ions, which can be attacked by different nucleophilic reagents to obtain various types of selenium sulfide compounds. When oleic acid, enol or enamine are used as substrates, the cyclized alkyl selenide sulfides can be obtained efficiently by this method. When aryl boric acid or aromatic ring are used as substrates, asymmetric aryl selenium sulfide compounds can be synthesized by this method. The method is simple and easy to operate, does not contain metal participation, fast and convenient, mild conditions, wide application range of reaction substrates, good regioselectivity, high yield, and can efficiently synthesize various types of selenium sulfide compounds.
【技术实现步骤摘要】
一种硒硫醚化合物的制备方法
：本专利技术涉及一种硒硫醚化合物的制备方法。
技术介绍
：有机硒硫化合物普遍存在于天然产物、药物和生物活性分子中((a)Dunbar,K.L.；Scharf,D.H.；Litomska,A.；Hertweck,C.Chem.Rev.2017,117,5521.(b)Chauhan,P.；Mahajan,S.；Enders,D.Chem.Rev.2014,114,8807.(c)Reich,H.J.；Hondal,R.J.；ACSChem.Biol.2016,11,821.)。通过直接C-S(C-Se)键的形成来构建有机硒硫化合物是一种重要的途径((a)Liu,H.；Jiang,X.Chem.AsianJ.2013,8,2546.(b)Shen,C.；Zhang,P.；Sun,Q.；Bai,S.；Hor,T.S.A.；Liu,X.Chem.Soc.Rev.2015,44,291.(c)Yu,J.-S.；Huang,H.-M.；Ding,P.-G.；Hu,X.-S.；Zhou,F.；Zhou,J.ACSCatal.2016,6,5319.)...
【技术保护点】
1.一种硒硫醚化合物的制备方法，其特征在于：其表达式为：
【技术特征摘要】
1.一种硒硫醚化合物的制备方法，其特征在于：其表达式为：式1化合物与R4EER4在溶剂中进行反应，催化剂为强酸和偶氮类化合物的混合物，所述强酸为三氟甲磺酸、三氟甲磺酸三甲基硅酯、三氟化硼—乙醚络合物或者双(三氟甲烷磺酰基)亚胺；所述偶氮类化合物为偶氮二甲酸二乙酯、偶氮二甲酸二异丙酯或偶氮二甲酸二苄酯；基团R1、R2、R3、R4为芳基或者烷基；E为S或者Se原子；n为1或2；所述溶剂为二氯甲烷、三氯甲烷或1,2-二氯乙烷。2.一种硒硫醚化合物的制备方法，其特征在于：其表达式为：式3化合物与二苯基二硫醚或二芳基二硒醚或二芳基二硫醚在溶剂中进行反应，催化剂为强酸和偶氮类化合物的混合物，所述强酸为三氟甲磺酸、三氟甲磺酸三甲基硅酯、三氟化硼—乙醚络合物或者双(三氟甲烷磺酰基)亚胺；所述偶氮类化合物为偶氮二甲酸二乙酯、偶氮二甲酸二异丙酯或偶氮二甲酸二苄酯；所述溶剂为二氯甲烷、三氯甲烷或1,2-二氯乙烷；基团R1、R2为芳基或...
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