眼镜蛇毒物理改性方法和在制备镇痛或免疫抑制药物中的应用技术

本发明专利技术公开了一种改性眼镜蛇毒及其改性方法和在制备镇痛和免疫抑制药物方面的应用，所述眼睛蛇毒来自中华眼镜蛇毒或泰国眼镜蛇毒，所述改性眼镜蛇毒是将眼镜蛇毒60-100℃加热5-120分钟后冷却后得到，且所述改性眼镜蛇毒用SDS-PAGE检测时出现特征性的小分子量蛋白的增加，药效增强，毒性下降。该改性眼镜蛇毒镇痛、抗炎抑制免疫作用明显，具有用量小、安全、可口服、可注射、可透过口鼻粘膜和皮肤给药等优点，具有较大的临床实用价值。

Physical modification method of cobra venom and application thereof in preparing analgesic or immunosuppressive drugs

The invention discloses a modified cobra venom and its modified method and preparation of analgesic and immunosuppressive drugs used in the system, the eyes from the venom of Chinese cobra venom or Thailand cobra venom, the modified cobra venom is obtained by cobra 60-100 C heating 5-120 minutes after cooling, and increased. The modified cobra venom protein with small molecular weight characteristic with SDS-PAGE detection of efficacy enhancement, decrease toxicity. The modified cobra venom has obvious analgesic, anti-inflammatory and immunosuppressive effects, and has the advantages of small dosage, safety, oral administration, injection, administration of the nose, mucous membrane and skin, and so on, and has great clinical practical value.

【技术实现步骤摘要】

【技术保护点】
１．一种改性眼镜蛇毒，其特征在于所述改性眼镜蛇毒来源于中华眼镜蛇毒或泰国眼镜蛇毒，所述改性眼镜蛇毒是将眼镜蛇毒６０－１００℃加热５－１２０分钟后冷却后得到，且所述改性眼镜蛇毒用ＳＤＳ－ＰＡＧＥ检测时出现特征性的小分子量蛋白的增加。

【技术特征摘要】

【专利技术属性】
技术研发人员：秦正红，祝佳丽，王进，史高娜，
申请(专利权)人：苏州大学，
类型：发明
国别省市：32