一种治疗骨髓炎的药物缓释制剂及制备方法和应用技术

本发明专利技术公开了一种治疗骨髓炎的药物缓释制剂及制备方法和应用，将消旋聚乳酸与左氧氟沙星按比例压制而成。其步骤是：A、将消旋聚乳酸剪碎与相应质量的左氧氟沙星粉末共置于有机溶剂中匀速搅拌至溶解；B、将共混物放入烘箱中加热使有机溶剂挥发，将干燥的共混物从容器壁上刮下；C、将共混物剪成适当块状，置于金属模具中初压，使共混块状物紧密结合成一整体；D、将模具连同其中的共混物置于烘箱中加热，压模定型，取出模具放入乳胶手套中置自来水中冷却，脱模，即消旋聚乳酸与左氧氟沙星的共混药片；E、塑料袋封装药片，60Co25KGy消毒。方法易行，给药方便，治疗效果显著，安全性高，药效时间长，适用于预防和治疗急性、慢性骨髓炎。

Medicine slow release preparation for treating osteomyelitis and preparation method and application thereof

The invention discloses a medicine slow release preparation for curing osteomyelitis, a preparation method and an application thereof, wherein, the racemic lactic acid and the levofloxacin are pressed in proportion. The method comprises the following steps: A, levofloxacin powder PDLLA shear and the corresponding quality were placed in uniform organic solvent, stirring to dissolve; B will blend in the oven heating makes the volatile organic solvent, the blend dry scraped from the wall of the container; C, will cut into appropriate bulk blends a metal mold, the initial pressure, the blend lumps are tightly combined into a whole; D, will die together with an oven which blends in heating, die shape, remove the mold into latex gloves in mid tap water cooling, demoulding, blending pills that poly DL lactic acid levofloxacin and left; E, plastic bag packaging 60Co25KGy disinfection tablets. The method has the advantages of easy operation, convenient administration, obvious curative effect, high safety and long efficacy, and is suitable for preventing and treating acute and chronic osteomyelitis.

【技术实现步骤摘要】

【技术保护点】
１．一种治疗骨髓炎的药物缓释制剂，它由以下质量比的原料制成：　　　　　　　原料　　　　　　　　　　　　　　　　　　　ｗ／ｗ消旋聚乳酸　　　　　　　　　　　５０％－９９％左氧氟沙星　　　　　　　　　　　１％－５０％；所述的消旋聚乳酸分子量１万～５０万。

【技术特征摘要】

【专利技术属性】
技术研发人员：汪晖，陈廖斌，曹洪，修涵，刘岩松，
申请(专利权)人：武汉大学，
类型：发明
国别省市：83