The invention provides a medicine application of small interfering RNA in the preparation of the treatment of colorectal cancer, this small interfering RNA can inhibit colon cancer cell proliferation, cell cycle arrest of colorectal cancer, colorectal cancer cells induced by apoptosis, downregulation of colorectal cancer mTOR / p70S6K / 4EBP1 signaling pathway activity, has therapeutic effect on colorectal cancer xenografts in nude mice, solves the problem of the use of chemotherapy in treatment of advanced colorectal cancer, the curative effect and prognosis of patients with technical problems are poor.
【技术实现步骤摘要】
【技术保护点】
一种小干扰ＲＮＡ在制备治疗大肠癌的药物中的应用，所述的小干扰ＲＮＡ正义链的５’→３’方向的核苷酸序列如ＳＥＱ ＩＤ ＮＯ：１所示，所述的小干扰ＲＮＡ反义链的５’→３’方向的核苷酸序列如ＳＥＱ ＩＤ ＮＯ：２所示。
【技术特征摘要】
【专利技术属性】
技术研发人员：房静远，张燕捷，
申请(专利权)人：上海交通大学医学院附属仁济医院，
类型：发明
国别省市：31[中国|上海]
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