The invention belongs to the technical field of tumor molecular biology and antibody preparation, and specifically discloses a long-chain non-coding RNA lncRNA 3608 and its antibody and application. According to the region of RNA lncRNA 3608P contained in long-chain non-coding RNA lncRNA 3608, it can encode and express polypeptide, and participate in the regulation of tumor cell migration and invasion. The polypeptide encoded by lncRNA 3608P or over-expression plasmid pHAGE lncRNA 3608P plays an important role in the pathogenesis of cervical cancer, ovarian cancer, endometrial cancer, breast cancer, colon cancer, liver cancer, glioma, lung cancer, pancreatic cancer or gastric cancer. The polypeptide and its antibodies produced by immune reaction can be used as new molecular markers and drug targets for the diagnosis and treatment of clinical cancer diseases. \u3002
【技术实现步骤摘要】
一种长链非编码RNAlncRNA-3608及其抗体与应用
本专利技术属于肿瘤分子生物学和抗体制备
,具体涉及一种长链非编码RNAlncRNA-3608及其抗体与应用。
技术介绍
近年来,非编码RNA在肿瘤细胞增殖、分化、转移和凋亡等生物学过程中发挥的调节作用是研究者们关心的焦点问题。长链非编码RNA(longnoncodingRNA,lncRNA)是一类转录本长度大于200nt(nucleotide),最初被认为是不翻译成蛋白质的功能性RNA分子(Science,2005,309(5740):1559-1563.)。近年来研究表明,lncRNA与许多癌症的发生和发展密切相关,如膀胱癌、乳腺癌、肝癌和前列腺癌等(Urology,2010,77(2):510.e1-510.e5..Nature,2010,464(7291):1071-1076.),也相继鉴定出一些具有编码多肽能力的lncRNA(Cell.2015Feb12;160(4):595-606;MolCell.2017Oct5;68(1):171-184.e6;Nature.2017Jan12;541( ...
【技术保护点】
1.一种长链非编码RNA lncRNA‑3608,其特征在于,其核酸序列如SEQ ID No:1所示,所述核苷酸序列中编码多肽的核苷酸序列如SEQ ID No:2,所述编码多肽的核苷酸序列的命名为lncRNA‑3608P。
【技术特征摘要】
1.一种长链非编码RNAlncRNA-3608,其特征在于,其核酸序列如SEQIDNo:1所示,所述核苷酸序列中编码多肽的核苷酸序列如SEQIDNo:2,所述编码多肽的核苷酸序列的命名为lncRNA-3608P。2.根据权利要求1所述的一种长链非编码RNAlncRNA-3608,其特征在于,所述多肽的氨基酸序列如SEQIDNo:3。3.含有权利要求1所述的编码多肽的核苷酸序列lncRNA-3608P的过表达质粒pHAGE-lncRNA-3608P。4.基于权利要求3所述的过表达质粒pHAGE-lncRNA-3608P的构建方法,其特征在于,包括如下步骤:合成获得SEQIDNo:2序列的目的基因,首...
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