The invention discloses a county alcohol extract of inflammatory bowel disease by treatment application in medicine preparation, including the preparation method wherein the alcohol extract of Nostoc Commune: Nostoc commune, with low carbon alcohol as solvent in extraction under the condition of heating, collecting the extract, solvent recovery, i.e.. The experimental results show that the county alcohol extract of UC mice were obviously improved weight DSS induced inhibition of DAI was significantly increased, decreased, reduce UC induced mouse colon shortening and inflammatory cell infiltration and reduce tissue injury. In addition, Nostoc commune alcohol extracts significantly decreased in the colonic tissue cells factor TNF alpha and IL 6 content, and this effect is related to the inhibition of inflammatory signal transduction of the key transcription factor B activation is closely related to NF. The experimental results show that the county alcohol extract can be used for the treatment of inflammatory bowel disease, alleviate the inflammatory reaction induced by DSS UC model, improve the degree of UC.
【技术实现步骤摘要】
地皮菜醇提物在制备治疗炎症性肠病药物中的应用
本专利技术涉及植物提取物的应用,具体涉及地皮菜醇提物在制备治疗炎症性肠病药物中的应用。
技术介绍
炎症性肠病(inflammatoryboweldisease,IBD)是一种主要累及回肠、直肠、结肠的一种特发性肠道炎症性疾病,临床表现为腹泻、腹痛,甚至可有血便。该病包括溃疡性结肠炎(ulcerativecolitis,UC)和克罗恩病(crohn’sdisease,CD)。溃疡性结肠炎是结肠黏膜层和黏膜下层连续性炎症,疾病通常先累及直肠,逐渐向全结肠蔓延;克罗恩病可累及全消化道,为非连续性全层炎症,最常累及部位为末端回肠、结肠和肛周。UC作为一种典型的炎症性肠病,好发于30-40岁青壮年,且无性别差异,表现为腹泻、腹痛、黏液脓血便等临床症状,多并发肠穿孔、息肉、溃疡等,严重影响患者生活质量和生存。流行病学研究表明,欧洲地区的UC发病率高达505/100,000,加拿大地区的发病率为248/100,000,美国的发病率为214/100,000。随着生活方式、饮食规律的改变,亚洲和中东等地区的UC发病率呈逐年增高的趋势。目 ...
【技术保护点】
地皮菜醇提物在制备治疗炎症性肠病药物或保健品中的应用。
【技术特征摘要】
1.地皮菜醇提物在制备治疗炎症性肠病药物或保健品中的应用。2.根据权利要求1所述的应用,其特征在于:所述地皮菜醇提物的制备方法包括:取地皮菜,以低碳醇为溶剂,于加热条件下提取,收集提取液,回收溶剂,即得到地皮菜醇提物。3.根据权利要求2所述的应用,其特征在于:所述地皮菜醇提物的制备方法进一步包括纯化步骤。4.根据权利要求3所述的应用,其特征在于:所述的纯化步骤为:取所得地皮菜醇提物用低碳醇重结晶,即得...
【专利技术属性】
技术研发人员:段小群,王宇晖,徐笑天,苑博,朱梦玲,曹后康,
申请(专利权)人:桂林医学院,
类型:发明
国别省市:广西,45
还没有人留言评论。发表了对其他浏览者有用的留言会获得科技券。