lincRNATUNAR在调节脑神经系统发育中应用技术方案
The application of lincRNATUNAR in the regulation of the development of the cerebral nerve system
The invention discloses a lincRNA TUNAR in regulation of cerebral nerve system development application. The inventor of GEO chip from the public database of the United States NCBI, by co expression analysis, the successful prediction of long non encoding TUNAR signal pathway in the development of nervous system: molecular function is closely related to the development of nervous system and other channels, 319 genes related to TUNAR related to the prognosis of the nervous system development. RNA SEQ sequencing results further indicate that in the nervous system tissues, high expression of TUNAR and protein related to the nervous system, but also high expression, there were very significant correlation (p< 0.0001). Based on this finding, we hope to clarify the mechanism of TUNAR causing brain dysplasia, and gradually establish the molecular regulatory network of neuronal differentiation, in order to provide a theoretical basis for finding new targets for the prevention and treatment of cerebral dysplasia.
【技术实现步骤摘要】
lincRNATUNAR在调节脑神经系统发育中应用
本专利技术涉及基于lncRNA的应用，特别涉及lincRNATUNAR在调节脑神经系统发育中应用。
技术介绍
先天性脑发育不良(CongenitalCerebralDysplasia)是一种异质性的疾病，新生儿脑发育异常,包括皮质增殖异常(abnormalcorticalproliferation)和神经元移行异常(abnormalneuronalmigration)[1]等多种类型。皮质增殖异常主要表现为小头畸形，小头畸形与神经系统异常和精神发育迟滞相关[2]。其诊断基础为颅底水平头围的测量，小于均值3SD以上为诊断标准。发生率约为1.6人每1000单胎分娩，只有14％出生时检测出的小头儿在1岁内诊断为小头畸形[2]。神经元移行异常的特点是脑回的缺失和皮层的增厚，并与大脑的其他异常有关，可表现为脑回缺如、脑回减少(无脑回)、单侧巨脑等[4]。这些疾病的相关发病机制尚不明确，无法进行有效的治疗，其针对性预防和治疗更为困难。虽然早发现、早干预胎儿脑发育异常,能减少出生缺陷,提高出生人口素质，但对其发病机制的探索仍非...
【技术保护点】
定量TUNAR表达量的试剂在制备脑神经系统疾病检测或筛查试剂中的应用。
【技术特征摘要】
1.定量TUNAR表达量的试剂在制备脑神经系统疾病检测或筛查试剂中的应用。2.根据权利要求1所述的应用，其特征在于：定量TUNAR表达量的试剂为RNA或DNA定量试剂。3.抑制TUNAR表达量的试剂在制备治疗脑神经系统疾病药物中的应用。4.抑制TUNAR表达产物活性的化合物或试剂在制备治疗脑神经系统疾病药物中的应用。5.根据权利要求1～4任一项所述的应用，其特征在于：脑神经系统疾病选自新生儿脑发育异常、先天...
【专利技术属性】
技术研发人员：陈梦麟，陈敏，张楠，黄凯铃，骆颖筠，刘艳卉，陈卓娜，史晓舜，乐小兵，
申请(专利权)人：陈梦麟，张楠，黄凯铃，骆颖筠，刘艳卉，
类型：发明
国别省市：广东,44
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