FGFR4抑制剂、其制备方法与药学上的应用技术

技术编号:20928509 阅读:26 留言:0更新日期:2019-04-20 12:23
提供一种具有式(Ⅰ)结构的FGFR4抑制剂及其制备方法和应用,该化合物对FGFR4激酶活性具有很强的抑制作用,并具有非常高的选择性,可广泛应用于制备治疗癌症特别是前列腺癌、肝癌、胰腺癌、食管癌、胃癌、肺癌、乳腺癌、卵巢癌、结肠癌、皮肤癌、神经胶质母细胞瘤或横纹肌肉瘤的药物,有望开发成新一代FGFR4抑制剂药物。

Fibroblast Growth Factor R4 Inhibitor, Its Preparation Method and Pharmaceutical Application

A novel (I) structured inhibitor of fibroblast growth factor receptor 4 (FGFR4) and its preparation method and application are provided. The compound has strong inhibitory effect on the activity of fibroblast growth factor receptor 4 kinase and high selectivity. It can be widely used in the preparation and treatment of cancer, especially prostate cancer, liver cancer, pancreatic cancer, esophageal cancer, gastric cancer, lung cancer, breast cancer, ovarian cancer, colon cancer, skin cancer and glial mother. Drugs for cell tumors or rhabdomyosarcoma are expected to be developed into a new generation of inhibitors of fibroblast growth factor R4.

【技术实现步骤摘要】
【国外来华专利技术】PCT国内申请,说明书已公开。

【技术保护点】
PCT国内申请,权利要求书已公开。

【技术特征摘要】
【国外来华专利技术】2016.12....

【专利技术属性】
技术研发人员:杨飞邓海兵应海燕喻红平陈椎徐耀昌
申请(专利权)人:上海和誉生物医药科技有限公司
类型:发明
国别省市:上海,31

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