一种表柔比星或其盐酸盐的分离纯化方法技术

本发明专利技术涉及一种表柔比星或其盐酸盐的分离纯化方法，包括1)取表柔比星或其盐酸盐粗品，上样大孔吸附树脂柱；2)用含体积百分比为5％‑50％的有机溶剂水溶液进行洗脱，收集合并洗脱液，分离得盐酸表柔比星。本发明专利技术的方法经济高效，对表柔比星或其盐酸盐粗品的杂质有非常好的选择性和分离效果，进行一次分离纯化就可得到药用级纯度的盐酸表柔比星，且收率高。

A method for separation and purification of epirubicin or its hydrochloride

The present invention relates to a separation and purification method of epirubicin or its hydrochloride, including 1) taking the epirubicin or its salt crude, the upper sample macroporous adsorption resin column, and 2) eluting the organic solvent water containing 5% volume percentage of the organic solvent, collecting the combined eluant and separating the epirubicin from the hydrochloric acid. The method of the invention is economical and efficient, and has very good selectivity and separation effect to the impurities of the epirubicin or its crude salt, and the purity of the drug can be obtained by one time separation and purification, and the yield is high.

【技术实现步骤摘要】
【国外来华专利技术】PCT国内申请，说明书已公开。

【技术保护点】
PCT国内申请，权利要求书已公开。

【技术特征摘要】
【国外来华专利技术】2015.11....

【专利技术属性】
技术研发人员：张福利，贾淼，裘鹏程，倪国伟，朱津津，汪有贵，毛文纲，严伟，
申请(专利权)人：浙江海正药业股份有限公司，上海医药工业研究院，
类型：发明
国别省市：浙江,33