The invention belongs to the field of gynecological disease prevention and control, and involves a new method of prevention and control of ovarian hyperstimulation syndrome. It is characterized by giving 0.2mg Triptorelin acetate for injection 12 hours after the GnRHa injection of antagonist regimen for patients with high risk of OHSS, and testing blood serum FSH, LH, E2, P and urine LH test. After 24 hours of 0.2mg's Triptorelin acetate for injection injection, the egg was routinely taken. After the egg was taken, the GnRH antagonist was given one day, and the embryo was given 3 days, and the embryo transfer was cancelled, and the follow-up was close. The vaginal ultrasound monitoring was performed on the day of taking eggs, first days after taking the eggs, second days after taking the eggs, and third days after the eggs were taken. The changes of bilateral ovarian size were recorded and the symptoms of abdominal distention were recorded. The invention has the advantages of simple and convenient operation, remarkable curative effect, can prevent and control moderate to severe OHSS, significantly improve the safety of auxiliary reproductive treatment, and can be widely used in the auxiliary reproductive treatment in the hospital.
【技术实现步骤摘要】
一种防治卵巢过度刺激综合征的新方法及应用
本专利技术属于妇科疾病的防治领域,涉及一种用于防治体外受精-胚胎移植(invitrofertilizationandembryotransfer,IVF-ET)中卵巢过度刺激综合征(ovarianhyperstimulationsyndrome,OHSS)的新方法及其临床应用,可在IVF周期中控制性超促排卵的高反应患者中应用来预防和治疗卵巢过度刺激综合征。
技术介绍
目前,由于工作节奏的加快和工作竞争压力的不断增强,以及环境污染等其他因素的综合影响下,不孕症患者的人数日益增加。临床工作中使用超促排卵造成患者多卵泡发育,经过IVF-ET实施受孕,已成为有效的医疗手段,但由此引发的卵巢过度刺激综合征不容忽视,OHSS根据症状的严重程度分为三度:轻度、中度和重度。OHSS总发病率为20%,其中三度OHSS发生率分别为20%-35%,3%-6%和0.1%-2%。重度患者如缺乏及时、适当的治疗,可能危及生命或遗留严重后遗症如OHSS严重增大的卵巢发生扭转后造成的卵巢缺血坏死、脑血栓导致的植物人等。在临床工作中,临床医生即使谨慎小心,因为患者个体差异比较大,OHSS仍然不可避免的时有发生。中重度OHSS患者多使用白蛋白、羟乙基淀粉、多巴胺激动剂、腹水抽吸、抗凝药物等多途径对症处理,重度患者需要住院治疗,严重者造成血栓导致局部功能障碍如下肢深静脉血栓、多器官功能障碍等,甚至生命危险。多途径对症治疗虽然在一定程度上能缓解患者的不适,但并不能完全避免重度卵巢过度刺激综合征的产生,而且重度OHSS显著增加了患者的身体不适和精神压力,且 ...
【技术保护点】
一种防治卵巢过度刺激综合征的新方法,其特征在于: 对于有OHSS高风险的患者,在拮抗剂方案的GnRHa注射之后的12小时给予0.2mg的注射用醋酸曲普瑞林,同时抽血检查血清FSH、LH、E2和P和尿LH试纸检测;在0.2mg的注射用醋酸曲普瑞林注射后24小时常规取卵,取卵后于取卵当日开始给予GnRH拮抗剂每日一支,连续3天,并且取消胚胎移植,密切随访,在取卵当天、取卵后第1天、取卵后第2天、取卵后第3天分别用阴道超声监测患者双侧卵巢大小变化,记录患者腹胀的自觉症状变化。
【技术特征摘要】
1.一种防治卵巢过度刺激综合征的新方法,其特征在于:对于有OHSS高风险的患者,在拮抗剂方案的GnRHa注射之后的12小时给予0.2mg的注射用醋酸曲普瑞林,同时抽血检查血清FSH、LH、E2和P和尿LH试纸检测;在0.2mg的注射用醋酸曲普瑞林注射后24小时常规取卵,取卵后于取卵当日开始给予GnRH拮抗剂每日一支,连续3天,并且取消胚胎移植,密切随访,在取卵当天、取卵后第1天、取卵后...
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