胆酸衍生物及其制备方法和医药用途技术

本发明专利技术涉及胆酸衍生物及其制备方法和医药用途。具体地，本发明专利技术涉及一种具有式(I)结构的胆酸衍生物、其立体异构体或其药学上可接受盐。该系列化合物可以用来治疗用于治疗FXR介导的疾病，包括心血管疾病、动脉粥样硬化、动脉硬化、高胆甾醇血、高血脂慢性肝炎疾病、慢性肝病、胃肠疾病、肾病、心血管疾病、代谢疾病、癌症(例如结直肠癌)或神经迹象如中风等疾病，具有广泛医学应用，有望开发成新一代FXR激动剂。

Cholic acid derivative, its preparation method and medical use

The present invention relates to cholic acid derivatives, their preparation methods and medical uses. Specifically, the present invention relates to a cholic acid derivative having a I structure, its stereoisomers, or pharmaceutically acceptable salts thereof. This series of compounds can be used in the treatment for the treatment of FXR mediated diseases, including cardiovascular disease, atherosclerosis, arteriosclerosis, high blood cholesterol, high blood lipid and chronic hepatitis, chronic liver disease, gastrointestinal disease, kidney disease, cardiovascular disease, metabolic disease, cancer (e.g. colorectal cancer) or neurological signs such as stroke and other diseases, has a wide range medical applications, is expected to develop into a new generation of FXR agonists.

【技术实现步骤摘要】
【国外来华专利技术】PCT国内申请，说明书已公开。

【技术保护点】
PCT国内申请，权利要求书已公开。

【技术特征摘要】
【国外来华专利技术】2015.04....

【专利技术属性】
技术研发人员：李成海，包如迪，吕爱锋，钟慧娟，
申请(专利权)人：江苏豪森药业集团有限公司，上海翰森生物医药科技有限公司，
类型：发明
国别省市：江苏,32