The invention discloses a methacryloyl benzimidazolone derivatives, the use of optical isomers, or the pharmaceutically acceptable salt or prodrug, (a) for the preparation of pharmaceutical compositions for reagent or down-regulation of PI3K/Akt pathway activity; (b) for treating or inhibiting tumor and / or drugs; reagent composition or inhibiting the growth of tumor cells; and / or (c) or pharmaceutical composition for reagents for cell cycle arrest. The present invention relates to compounds can down regulate the phosphorylation of Akt in P13K/Akt signaling pathway, and the effect of new small molecule drugs targeting MK2206; and cell level, methacryloyl benzimidazolone derivatives represented by FD1 has good inhibition effect on the proliferation of tumor cells, and MK2206 is different better, the role of FD1 cells on PTEN deficient effect.
【技术实现步骤摘要】
【国外来华专利技术】PCT国内申请,说明书已公开。
【技术保护点】
PCT国内申请,权利要求书已公开。
【技术特征摘要】
【国外来华专利技术】2014.03....
【专利技术属性】
技术研发人员:李家鹏,姬志勤,周晓亚,魏少鹏,钱勇,谢天培,
申请(专利权)人:上海诗丹德生物技术有限公司,
类型:发明
国别省市:上海,31
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